HCSGD entry for PTH


1. General information

Official gene symbolPTH
Entrez ID5741
Gene full nameparathyroid hormone
Other gene symbolsPTH1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001501Skeletal system developmentTASbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIMPmolecular_function
GO:0005179Hormone activityIEAmolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIMPbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0007267Cell-cell signalingIEAbiological_process
GO:0008628Hormone-mediated apoptotic signaling pathwayTASbiological_process
GO:0009967Positive regulation of signal transductionIEAbiological_process
GO:0010288Response to lead ionIEAbiological_process
GO:0010468Regulation of gene expressionIDAbiological_process
GO:0030501Positive regulation of bone mineralizationIDAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0031857Type 1 parathyroid hormone receptor bindingIEAmolecular_function
GO:0033280Response to vitamin DIEAbiological_process
GO:0034645Cellular macromolecule biosynthetic processIDAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0045453Bone resorptionNASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046058CAMP metabolic processTASbiological_process
GO:0046326Positive regulation of glucose importIDAbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:0051428Peptide hormone receptor bindingIDAmolecular_function
GO:0071107Response to parathyroid hormoneIEAbiological_process
GO:0071774Response to fibroblast growth factorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.67959740890.83039899320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0695477478
GSE13712_SHEARDown-0.0767002039
GSE13712_STATICUp0.0677843541
GSE19018Up0.1781624462
GSE19899_A1Up0.0490585693
GSE19899_A2Down-0.0671240038
PubMed_21979375_A1Down-0.0718169235
PubMed_21979375_A2Up0.0573655969
GSE35957Down-0.0911377906
GSE36640Down-0.0229617880
GSE54402Down-0.0217710717
GSE9593Up0.0135252842
GSE43922Up0.0173583427
GSE24585Up0.0292490891
GSE37065Up0.0498845175
GSE28863_A1Down-0.1236077010
GSE28863_A2Down-0.1255865268
GSE28863_A3Up0.1080361175
GSE28863_A4Up0.2221036466
GSE48662Up0.0148583864

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NorleucineDB04419 EXPT02355
ABX-PTHDB05883 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018218MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2523707050) that persisted after adjustment for age, sex, diabetes mellitus, clinical history of cardiovascular disease, inflammation, use of vitamin D, and serum levels of phosphate and intact parathyroid hormone
22696456PTH demonstrated age-dependent effects upon GJIC: Osteoblastic cells from young rats increased GJIC in response to PTH, whereas there was no change in GJIC in response to PTH in osteoblastic cells from mature or old rats
22696456These data demonstrate an age-related impairment in the capacity of osteoblastic cells to generate functional gap junctions in response to PTH, and suggest that an age-related defect in G protein-coupled adenylate cyclase activity at least partially contributes to decreased PTH-stimulated GJIC
11037877METHODS: We examined age-related changes in cellular activity (alkaline phosphatase activity, osteocalcin and C-terminal type I procollagen secretion, and cAMP response to parathyroid hormone), replicative capacity, and senescent cell expression in osteoblasts from periarticular bone samples obtained from 15 patients with RA and 15 age-matched patients with osteoarthritis (OA)
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