HCSGD entry for PTH
1. General information
Official gene symbol | PTH |
---|---|
Entrez ID | 5741 |
Gene full name | parathyroid hormone |
Other gene symbols | PTH1 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
GO:0001501 | Skeletal system development | TAS | biological_process |
GO:0003705 | RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | IMP | molecular_function |
GO:0005179 | Hormone activity | IEA | molecular_function |
GO:0005576 | Extracellular region | NAS TAS | cellular_component |
GO:0005615 | Extracellular space | IEA | cellular_component |
GO:0006366 | Transcription from RNA polymerase II promoter | IMP | biological_process |
GO:0006874 | Cellular calcium ion homeostasis | IEA | biological_process |
GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
GO:0007189 | Adenylate cyclase-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
GO:0007266 | Rho protein signal transduction | IEA | biological_process |
GO:0007267 | Cell-cell signaling | IEA | biological_process |
GO:0008628 | Hormone-mediated apoptotic signaling pathway | TAS | biological_process |
GO:0009967 | Positive regulation of signal transduction | IEA | biological_process |
GO:0010288 | Response to lead ion | IEA | biological_process |
GO:0010468 | Regulation of gene expression | IDA | biological_process |
GO:0030501 | Positive regulation of bone mineralization | IDA | biological_process |
GO:0030819 | Positive regulation of cAMP biosynthetic process | IDA | biological_process |
GO:0031857 | Type 1 parathyroid hormone receptor binding | IEA | molecular_function |
GO:0033280 | Response to vitamin D | IEA | biological_process |
GO:0034645 | Cellular macromolecule biosynthetic process | IDA | biological_process |
GO:0042493 | Response to drug | IEA | biological_process |
GO:0045453 | Bone resorption | NAS | biological_process |
GO:0045471 | Response to ethanol | IEA | biological_process |
GO:0045725 | Positive regulation of glycogen biosynthetic process | IDA | biological_process |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
GO:0046058 | CAMP metabolic process | TAS | biological_process |
GO:0046326 | Positive regulation of glucose import | IDA | biological_process |
GO:0046686 | Response to cadmium ion | IEA | biological_process |
GO:0051428 | Peptide hormone receptor binding | IDA | molecular_function |
GO:0071107 | Response to parathyroid hormone | IEA | biological_process |
GO:0071774 | Response to fibroblast growth factor | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.6795974089 | 0.8303989932 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0695477478 |
GSE13712_SHEAR | Down | -0.0767002039 |
GSE13712_STATIC | Up | 0.0677843541 |
GSE19018 | Up | 0.1781624462 |
GSE19899_A1 | Up | 0.0490585693 |
GSE19899_A2 | Down | -0.0671240038 |
PubMed_21979375_A1 | Down | -0.0718169235 |
PubMed_21979375_A2 | Up | 0.0573655969 |
GSE35957 | Down | -0.0911377906 |
GSE36640 | Down | -0.0229617880 |
GSE54402 | Down | -0.0217710717 |
GSE9593 | Up | 0.0135252842 |
GSE43922 | Up | 0.0173583427 |
GSE24585 | Up | 0.0292490891 |
GSE37065 | Up | 0.0498845175 |
GSE28863_A1 | Down | -0.1236077010 |
GSE28863_A2 | Down | -0.1255865268 |
GSE28863_A3 | Up | 0.1080361175 |
GSE28863_A4 | Up | 0.2221036466 |
GSE48662 | Up | 0.0148583864 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-335-5p | MIMAT0000765 | MIRT018218 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
25237070 | 50) that persisted after adjustment for age, sex, diabetes mellitus, clinical history of cardiovascular disease, inflammation, use of vitamin D, and serum levels of phosphate and intact parathyroid hormone |
22696456 | PTH demonstrated age-dependent effects upon GJIC: Osteoblastic cells from young rats increased GJIC in response to PTH, whereas there was no change in GJIC in response to PTH in osteoblastic cells from mature or old rats |
22696456 | These data demonstrate an age-related impairment in the capacity of osteoblastic cells to generate functional gap junctions in response to PTH, and suggest that an age-related defect in G protein-coupled adenylate cyclase activity at least partially contributes to decreased PTH-stimulated GJIC |
11037877 | METHODS: We examined age-related changes in cellular activity (alkaline phosphatase activity, osteocalcin and C-terminal type I procollagen secretion, and cAMP response to parathyroid hormone), replicative capacity, and senescent cell expression in osteoblasts from periarticular bone samples obtained from 15 patients with RA and 15 age-matched patients with osteoarthritis (OA) |
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