HCSGD entry for PTGIR

1. General information

Official gene symbolPTGIR
Entrez ID5739
Gene full nameprostaglandin I2 (prostacyclin) receptor (IP)
Other gene symbolsIP PRIPR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEA IMPbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010642Negative regulation of platelet-derived growth factor receptor signaling pathwayIEA ISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030819Positive regulation of cAMP biosynthetic processIEA IMPbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0043087Regulation of GTPase activityTASbiological_process
GO:0043950Positive regulation of cAMP-mediated signalingIEA IMPbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10083742640.96095171540.66188077311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1916074149
GSE13712_SHEARUp0.1284758815
GSE13712_STATICUp0.0874605436
GSE19018Up0.1569982363
GSE19899_A1Up0.0051998161
GSE19899_A2Up0.3260864065
PubMed_21979375_A1Up0.5898283626
PubMed_21979375_A2Down-0.1741823938
GSE35957Up0.4256209401
GSE36640Up0.0796418477
GSE54402Up0.1200938575
GSE9593Down-0.0604118966
GSE43922Up0.1839192063
GSE24585Up0.0099442808
GSE37065Up0.1882388560
GSE28863_A1Up0.0680211664
GSE28863_A2Down-0.0474928689
GSE28863_A3Up0.1280577844
GSE28863_A4Up0.1931894716
GSE48662Up0.3818452550

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IloprostDB01088 APRD01027
Dinoprost TromethamineDB01160 APRD00926
EpoprostenolDB01240 APRD00949
BeraprostDB05229 -
SelexipagDB11362 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.