HCSGD entry for PTGER4

1. General information

Official gene symbolPTGER4
Entrez ID5734
Gene full nameprostaglandin E receptor 4 (subtype EP4)
Other gene symbolsEP4 EP4R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004957Prostaglandin E receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006955Immune responseIEPbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007254JNK cascadeISSbiological_process
GO:0009612Response to mechanical stimulusIEPbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0030278Regulation of ossificationIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0033624Negative regulation of integrin activationIDAbiological_process
GO:0042093T-helper cell differentiationISSbiological_process
GO:0050710Negative regulation of cytokine secretionISSbiological_process
GO:0050715Positive regulation of cytokine secretionISSbiological_process
GO:0050728Negative regulation of inflammatory responseIDAbiological_process
GO:0050729Positive regulation of inflammatory responseISSbiological_process
GO:0051492Regulation of stress fiber assemblyISSbiological_process
GO:0060348Bone developmentISSbiological_process
GO:0070371ERK1 and ERK2 cascadeISSbiological_process
GO:0071260Cellular response to mechanical stimulusISSbiological_process
GO:2000420Negative regulation of eosinophil extravasationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00597302530.95491029220.20364766841.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1118647293
GSE13712_SHEARUp1.1951371267
GSE13712_STATICUp0.7455129369
GSE19018Up0.3191616857
GSE19899_A1Up0.4163805826
GSE19899_A2Up0.3512420424
PubMed_21979375_A1Up1.0365705635
PubMed_21979375_A2Up0.1565777399
GSE35957Down-0.0160366471
GSE36640Up1.2246397870
GSE54402Up0.5717773495
GSE9593Up0.3905695968
GSE43922Up0.0467425781
GSE24585Down-0.1497674887
GSE37065Up0.2956064565
GSE28863_A1Down-0.2286124413
GSE28863_A2Up0.5703910446
GSE28863_A3Up0.0912224825
GSE28863_A4Down-0.0277733349
GSE48662Up0.4211289899

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MisoprostolDB00929 APRD00037

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.