HCSGD entry for CBX8
1. General information
| Official gene symbol | CBX8 |
|---|---|
| Entrez ID | 57332 |
| Gene full name | chromobox homolog 8 |
| Other gene symbols | PC3 RC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0000151 | Ubiquitin ligase complex | IEA | cellular_component |
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0003727 | Single-stranded RNA binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0016574 | Histone ubiquitination | IEA | biological_process |
| GO:0031519 | PcG protein complex | IDA IEA | cellular_component |
| GO:0035064 | Methylated histone residue binding | IDA | molecular_function |
| GO:0035102 | PRC1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5395343756 | 0.7188843927 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0876734579 |
| GSE13712_SHEAR | Up | 0.1958254629 |
| GSE13712_STATIC | Up | 0.1213707601 |
| GSE19018 | Up | 0.1484016430 |
| GSE19899_A1 | Down | -0.1988610698 |
| GSE19899_A2 | Up | 0.5222743303 |
| PubMed_21979375_A1 | Down | -0.7422146795 |
| PubMed_21979375_A2 | Up | 0.1444037322 |
| GSE35957 | Up | 0.0232519568 |
| GSE36640 | Up | 0.0131749521 |
| GSE54402 | Down | -0.2928976003 |
| GSE9593 | Down | -0.1529692146 |
| GSE43922 | Up | 0.0551909397 |
| GSE24585 | Up | 0.0153713544 |
| GSE37065 | Up | 0.0250600323 |
| GSE28863_A1 | Down | -0.0049963538 |
| GSE28863_A2 | Down | -0.0316373998 |
| GSE28863_A3 | Up | 0.4758283415 |
| GSE28863_A4 | Up | 0.0187025814 |
| GSE48662 | Down | -0.0220276088 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19636380 | Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repress INK4a, both participate in PRC1-like complexes with at least two Posterior sex combs (Psc) proteins, MEL18 and BMI1 |
| 19636380 | In primary human fibroblasts, CBX7, CBX8, MEL18 and BMI1 are present at the INK4a locus and shRNA-mediated knockdown of any one of these components results in de-repression of INK4a and proliferative arrest |
| 19636380 | Sequential chromatin immunoprecipitation (ChIP) reveals that CBX7 and CBX8 bind simultaneously to the same region of chromatin and knockdown of one of the Pc or Psc proteins results in release of the other, suggesting that the binding of PRC1 complexes is interdependent |
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