HCSGD entry for PTCH1

1. General information

Official gene symbolPTCH1
Entrez ID5727
Gene full namepatched 1
Other gene symbolsBCNS HPE7 NBCCS PTC PTC1 PTCH PTCH11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001843Neural tube closureIEAbiological_process
GO:0003007Heart morphogenesisIEAbiological_process
GO:0005113Patched bindingIEAmolecular_function
GO:0005119Smoothened bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0005901CaveolaIDAcellular_component
GO:0007224Smoothened signaling pathwayIEP ISSbiological_process
GO:0007346Regulation of mitotic cell cycleIEAbiological_process
GO:0007420Brain developmentIEA ISSbiological_process
GO:0008158Hedgehog receptor activityIEAmolecular_function
GO:0008201Heparin bindingIEAmolecular_function
GO:0008544Epidermis developmentIEAbiological_process
GO:0008589Regulation of smoothened signaling pathwayIEA ISSbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009887Organ morphogenesisISSbiological_process
GO:0009953Dorsal/ventral pattern formationISSbiological_process
GO:0010157Response to chlorateIEAbiological_process
GO:0010875Positive regulation of cholesterol effluxIDAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015485Cholesterol bindingIDAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0016485Protein processingIEA ISSbiological_process
GO:0021522Spinal cord motor neuron differentiationIEAbiological_process
GO:0021532Neural tube patterningIMPbiological_process
GO:0021997Neural plate axis specificationIEA ISSbiological_process
GO:0030326Embryonic limb morphogenesisIEA ISSbiological_process
GO:0030332Cyclin bindingIEA IPImolecular_function
GO:0030496MidbodyIEAcellular_component
GO:0032355Response to estradiolIEAbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032880Regulation of protein localizationIEAbiological_process
GO:0035108Limb morphogenesisIMPbiological_process
GO:0035137Hindlimb morphogenesisIEAbiological_process
GO:0040015Negative regulation of multicellular organism growthIEA ISSbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0043616Keratinocyte proliferationIEAbiological_process
GO:0044294Dendritic growth coneIEAcellular_component
GO:0044295Axonal growth coneIEAcellular_component
GO:0045668Negative regulation of osteoblast differentiationIMPbiological_process
GO:0045879Negative regulation of smoothened signaling pathwayISS TASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0051782Negative regulation of cell divisionIEAbiological_process
GO:0060037Pharyngeal system developmentIMPbiological_process
GO:0060603Mammary gland duct morphogenesisIEAbiological_process
GO:0060644Mammary gland epithelial cell differentiationIEAbiological_process
GO:0060831Smoothened signaling pathway involved in dorsal/ventral neural tube patterningIEAbiological_process
GO:0061005Cell differentiation involved in kidney developmentIEAbiological_process
GO:0061053Somite developmentIEA IMPbiological_process
GO:0071397Cellular response to cholesterolIEA IMP ISSbiological_process
GO:0072001Renal system developmentIEPbiological_process
GO:0072203Cell proliferation involved in metanephros developmentIEAbiological_process
GO:0072372Primary ciliumIEAcellular_component
GO:0072661Protein targeting to plasma membraneIDAbiological_process
GO:0097108Hedgehog family protein bindingIPImolecular_function
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89802400360.12423301550.99999024730.6773079950

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0045645043
GSE13712_SHEARDown-0.2455016698
GSE13712_STATICDown-0.2582319620
GSE19018Up0.0905339190
GSE19899_A1Up0.0063760202
GSE19899_A2Down-0.4736198335
PubMed_21979375_A1Down-0.4579997996
PubMed_21979375_A2Down-0.2463742452
GSE35957Down-0.1288694763
GSE36640Up0.1504423918
GSE54402Down-0.5039313738
GSE9593Down-0.0615465884
GSE43922Down-0.4315777353
GSE24585Up0.4646111520
GSE37065Up0.0468372588
GSE28863_A1Down-0.1279985284
GSE28863_A2Down-0.2177937702
GSE28863_A3Up0.2325109360
GSE28863_A4Up0.1627771359
GSE48662Up0.0222783594

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-212-3pMIMAT0000269MIRT006293Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22357618
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27229128Using Ptch1+/- mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution
27229128Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event associated with cell senescence in preneoplasia
27229128These findings are consistent with a model where high levels of Hedgehog signaling caused by the loss of the tumor suppressor Ptch1 lead to oncogene-induced senescence and drive p53 mutations
26997276Using Ptch1(+/-) mice to study medulloblastoma progression, we found that Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell senescence in preneoplasia
26997276Consistent with senescence evasion, these p53 mutations are always subsequent to Ptch1 LOH
26997276Altogether, our results show that evasion of senescence associated with Ptch1 LOH allows progression to advanced tumors
25645196FINDINGS: Here we show that beta-catenin stabilization by the glycogen synthase kinase 3 inhibitor lithium chloride (LiCl) reduced growth of primary hedgehog-driven MB tumor spheres from patched heterozygous mice (Ptch(+/-)) in vitro
Entries Per Page
Displaying Page of