HCSGD entry for PTBP1
1. General information
| Official gene symbol | PTBP1 |
|---|---|
| Entrez ID | 5725 |
| Gene full name | polypyrimidine tract binding protein 1 |
| Other gene symbols | HNRNP-I HNRNPI HNRPI PTB PTB-1 PTB-T PTB2 PTB3 PTB4 pPTB |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000380 | Alternative mRNA splicing, via spliceosome | IEA | biological_process |
| GO:0000381 | Regulation of alternative mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | TAS | cellular_component |
| GO:0006397 | MRNA processing | IEA TAS | biological_process |
| GO:0008187 | Poly-pyrimidine tract binding | TAS | molecular_function |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0033119 | Negative regulation of RNA splicing | IDA | biological_process |
| GO:0036002 | Pre-mRNA binding | IDA | molecular_function |
| GO:0048025 | Negative regulation of mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0051148 | Negative regulation of muscle cell differentiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9756213974 | 0.1671070932 | 0.9999902473 | 0.7900890605 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0841686599 |
| GSE13712_SHEAR | Down | -0.0303786376 |
| GSE13712_STATIC | Down | -0.1761303217 |
| GSE19018 | Down | -0.4898027779 |
| GSE19899_A1 | Down | -0.1188279492 |
| GSE19899_A2 | Down | -0.1878877756 |
| PubMed_21979375_A1 | Up | 0.4307210322 |
| PubMed_21979375_A2 | Down | -0.0738147469 |
| GSE35957 | Down | -0.0401283860 |
| GSE36640 | Down | -0.4915275943 |
| GSE54402 | Up | 0.2052470157 |
| GSE9593 | Down | -0.2254329790 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2051053091 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001345 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002647 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002647 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039680 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040624 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043938 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046541 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049413 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049932 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050776 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050898 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
