HCSGD entry for PSME1

1. General information

Official gene symbolPSME1
Entrez ID5720
Gene full nameproteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Other gene symbolsIFI5111 PA28A PA28alpha REGalpha
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008537Proteasome activator complexIEAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0061133Endopeptidase activator activityIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51574365340.03605125950.99999024730.3581466717

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1627292088
GSE13712_SHEARUp0.0504263261
GSE13712_STATICUp0.3212138597
GSE19018Up0.1038513240
GSE19899_A1Down-1.2279337629
GSE19899_A2Down-0.7715236578
PubMed_21979375_A1Down-1.3896305909
PubMed_21979375_A2Down-1.3858541472
GSE35957Down-0.7732808027
GSE36640Up0.2506189543
GSE54402Down-0.4939517896
GSE9593Up0.3458720635
GSE43922Down-0.9041400309
GSE24585Up0.4253175511
GSE37065Up0.4540562700
GSE28863_A1Down-0.0818085192
GSE28863_A2Down-0.0355601218
GSE28863_A3Up0.0116528950
GSE28863_A4Up0.1615539342
GSE48662Up0.1202736897

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023950ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT029951MicroarrayFunctional MTI (Weak)19088304
hsa-miR-421MIMAT0003339MIRT039420CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043135CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043440CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045261CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.