HCSGD entry for PSMD10

1. General information

Official gene symbolPSMD10
Entrez ID5716
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Other gene symbolsdJ889N15.2 p28 p28(GANK)
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005838Proteasome regulatory particleTAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0007253Cytoplasmic sequestering of NF-kappaBIDAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008540Proteasome regulatory particle, base subcomplexIDAcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0031398Positive regulation of protein ubiquitinationIMPbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032436Positive regulation of proteasomal ubiquitin-dependent protein catabolic processIDA TASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIDA IMP TASbiological_process
GO:0043409Negative regulation of MAPK cascadeIMPbiological_process
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0045737Positive regulation of cyclin-dependent protein kinase activityIDAbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0070682Proteasome regulatory particle assemblyIMPbiological_process
GO:0090201Negative regulation of release of cytochrome c from mitochondriaIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20602850960.39427980320.87493972251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2832675565
GSE13712_SHEARUp0.3706883156
GSE13712_STATICUp0.1164976123
GSE19018Up0.3474160811
GSE19899_A1Up0.3116808803
GSE19899_A2Down-0.2118200066
PubMed_21979375_A1Down-0.9947876898
PubMed_21979375_A2Down-0.5723801079
GSE35957Down-0.0755426684
GSE36640Up0.1556299920
GSE54402Down-0.0003062088
GSE9593Up0.0797860531
GSE43922Up0.0474981660
GSE24585Down-0.2388683978
GSE37065Up0.2494850931
GSE28863_A1Up0.0321063838
GSE28863_A2Down-0.0060323237
GSE28863_A3Down-0.5668669653
GSE28863_A4Up0.3468047819
GSE48662Down-0.3641017348

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT023306ProteomicsFunctional MTI (Weak)21750653
hsa-miR-214-3pMIMAT0000271MIRT035545Luciferase reporter assayFunctional MTI23100276
hsa-miR-877-3pMIMAT0004950MIRT036871CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044545CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.