HCSGD entry for SMURF1

1. General information

Official gene symbolSMURF1
Entrez ID57154
Gene full nameSMAD specific E3 ubiquitin protein ligase 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIBAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006611Protein export from nucleusIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007398Ectoderm developmentTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0030154Cell differentiationIDAbiological_process
GO:0030279Negative regulation of ossificationIEAbiological_process
GO:0030509BMP signaling pathwayIDA TASbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIDA TASbiological_process
GO:0030514Negative regulation of BMP signaling pathwayTASbiological_process
GO:0030579Ubiquitin-dependent SMAD protein catabolic processIDAbiological_process
GO:0032801Receptor catabolic processIDAbiological_process
GO:0034394Protein localization to cell surfaceIDAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0048185Activin bindingNASmolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04024645720.96327452600.45034900131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0452900671
GSE13712_SHEARUp0.5242316590
GSE13712_STATICUp0.3235115313
GSE19018Down-0.0955141064
GSE19899_A1Up0.1758215740
GSE19899_A2Up0.3744814386
PubMed_21979375_A1Up0.7513873037
PubMed_21979375_A2Up0.9882495741
GSE35957Up0.0336531308
GSE36640Up0.0844213597
GSE54402Up0.1739739385
GSE9593Down-0.2079024529
GSE43922Up0.5235075007
GSE24585Down-0.0735342547
GSE37065Up0.3329911745
GSE28863_A1Up0.3085872267
GSE28863_A2Up0.4922776153
GSE28863_A3Down-0.0883024054
GSE28863_A4Down-0.2337706537
GSE48662Down-0.0743712992

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-424-5pMIMAT0001341MIRT042442CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.