HCSGD entry for NUP107
1. General information
| Official gene symbol | NUP107 |
|---|---|
| Entrez ID | 57122 |
| Gene full name | nucleoporin 107kDa |
| Other gene symbols | NUP84 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0005487 | Nucleocytoplasmic transporter activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005635 | Nuclear envelope | TAS | cellular_component |
| GO:0005643 | Nuclear pore | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006406 | MRNA export from nucleus | IDA | biological_process |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0007077 | Mitotic nuclear envelope disassembly | TAS | biological_process |
| GO:0008645 | Hexose transport | TAS | biological_process |
| GO:0010827 | Regulation of glucose transport | TAS | biological_process |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0015758 | Glucose transport | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0017056 | Structural constituent of nuclear pore | IMP | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0031080 | Nuclear pore outer ring | IDA NAS | cellular_component |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0034399 | Nuclear periphery | IDA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051292 | Nuclear pore complex assembly | IMP | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9835482732 | 0.0031887238 | 0.9999902473 | 0.1140358696 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0474468245 |
| GSE13712_SHEAR | Up | 0.0595282636 |
| GSE13712_STATIC | Down | -0.1842761903 |
| GSE19018 | Down | -0.5378153683 |
| GSE19899_A1 | Down | -0.6435848287 |
| GSE19899_A2 | Down | -1.1336279170 |
| PubMed_21979375_A1 | Down | -0.6968101323 |
| PubMed_21979375_A2 | Down | -1.0785110956 |
| GSE35957 | Down | -0.8391508823 |
| GSE36640 | Down | -1.3941842334 |
| GSE54402 | Down | -0.1757848864 |
| GSE9593 | Down | -0.6094585543 |
| GSE43922 | Down | -0.1642840742 |
| GSE24585 | Down | -0.0929995418 |
| GSE37065 | Down | -0.2361717187 |
| GSE28863_A1 | Down | -0.4897948979 |
| GSE28863_A2 | Up | 0.3532529809 |
| GSE28863_A3 | Down | -0.1399834642 |
| GSE28863_A4 | Up | 0.1161626729 |
| GSE48662 | Down | -0.7092188487 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT028013 | Sequencing | Functional MTI (Weak) | 20371350 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20833136 | Reduction of Nup107 attenuates the growth factor signaling in the senescent cells |
| 20833136 | In this study, we found markedly decreased level of Nup107, a key scaffold protein in nuclear pore complex assembly, in senescent human diploid fibroblasts as well as in organs of aged mice |
| 20833136 | Depletion of Nup107 by specific siRNA in young human diploid fibroblasts prevented the effective nuclear translocation of phosphorylated extracellular signal-regulated kinase (ERK) following epidermal growth factor (EGF) stimulation, and decreased the expression of c-Fos in consequence |
| 20833136 | Knockdown of Nup107 in anaplastic oligodendroglioma cells caused cell death, rather than growth retardation, indicating a greater sensitivity to Nup107 depletion in cancer cells than in normal cells |
| 20833136 | These findings support the notion that Nup107 may contribute significantly to the regulation of cell fate in aged and transformed cells by modulating nuclear trafficking of signal molecules |
Entries Per Page
Displaying Page of
