HCSGD entry for PSMD3

1. General information

Official gene symbolPSMD3
Entrez ID5709
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Other gene symbolsP58 RPN3 S3 TSTA2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIEA TAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0022624Proteasome accessory complexISScellular_component
GO:0030234Enzyme regulator activityIEAmolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042176Regulation of protein catabolic processIEAbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06207614070.67764239200.53912191831.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6407394948
GSE13712_SHEARDown-0.0107004739
GSE13712_STATICUp0.1720613878
GSE19018Down-0.0091834364
GSE19899_A1Up0.3036312610
GSE19899_A2Up0.6156957995
PubMed_21979375_A1Up0.4813728261
PubMed_21979375_A2Down-2.0968650347
GSE35957Down-0.1497115219
GSE36640Up0.3230076528
GSE54402Up0.5284954570
GSE9593Down-0.2249426030
GSE43922Up0.2547515906
GSE24585Down-0.1035061596
GSE37065Down-0.1250619731
GSE28863_A1Up0.1643226714
GSE28863_A2Up0.3395617406
GSE28863_A3Down-0.2932270755
GSE28863_A4Up0.0890788630
GSE48662Up0.0778410712

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-760MIMAT0004957MIRT036722CLASHFunctional MTI (Weak)23622248
hsa-miR-769-5pMIMAT0003886MIRT039148CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040625CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-5pMIMAT0000731MIRT044009CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045113CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049247CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.