HCSGD entry for PSMD1

1. General information

Official gene symbolPSMD1
Entrez ID5707
Gene full nameproteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Other gene symbolsP112 Rpn2 S1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexTAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005838Proteasome regulatory particleTAScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0022624Proteasome accessory complexISScellular_component
GO:0030234Enzyme regulator activityIEAmolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042176Regulation of protein catabolic processIEAbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88018325670.12732576270.99999024730.6870318573

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1458653162
GSE13712_SHEARDown-0.1990736895
GSE13712_STATICUp0.0795951681
GSE19018Down-0.1081655488
GSE19899_A1Down-0.2837084336
GSE19899_A2Down-0.2806592324
PubMed_21979375_A1Down-0.7284915301
PubMed_21979375_A2Down-0.1661090034
GSE35957Up0.0399010678
GSE36640Down-0.1005916460
GSE54402Up0.2143934207
GSE9593Up0.0022745156
GSE43922Down-0.2269210385
GSE24585Down-0.0309197955
GSE37065Up0.0899878001
GSE28863_A1Down-0.0576322819
GSE28863_A2Up0.5657326019
GSE28863_A3Down-0.7506494805
GSE28863_A4Down-0.0838686985
GSE48662Down-0.1426810861

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-24-3pMIMAT0000080MIRT030387MicroarrayFunctional MTI (Weak)19748357
hsa-miR-1180-3pMIMAT0005825MIRT035921CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042491CLASHFunctional MTI (Weak)23622248
hsa-miR-346MIMAT0000773MIRT042702CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043445CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045451CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.