HCSGD entry for TBX20

1. General information

Official gene symbolTBX20
Entrez ID57057
Gene full nameT-box 20
Other gene symbolsASD4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingISSmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingISSmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityIDAmolecular_function
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001706Endoderm formationISSbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001947Heart loopingISSbiological_process
GO:0003143Embryonic heart tube morphogenesisISSbiological_process
GO:0003148Outflow tract septum morphogenesisIMPbiological_process
GO:0003175Tricuspid valve developmentISSbiological_process
GO:0003180Aortic valve morphogenesisIMPbiological_process
GO:0003193Pulmonary valve formationISSbiological_process
GO:0003203Endocardial cushion morphogenesisISSbiological_process
GO:0003207Cardiac chamber formationISSbiological_process
GO:0003215Cardiac right ventricle morphogenesisISSbiological_process
GO:0003272Endocardial cushion formationISSbiological_process
GO:0003279Cardiac septum developmentISSbiological_process
GO:0003344Pericardium morphogenesisISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmISScellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006936Muscle contractionIEAbiological_process
GO:0008015Blood circulationIEAbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0009953Dorsal/ventral pattern formationISSbiological_process
GO:0010991Negative regulation of SMAD protein complex assemblyIEAbiological_process
GO:0021524Visceral motor neuron differentiationISSbiological_process
GO:0035922Foramen ovale closureIMPbiological_process
GO:0036306Embryonic heart tube elongationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048370Lateral mesoderm formationISSbiological_process
GO:0055008Cardiac muscle tissue morphogenesisISSbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationISSbiological_process
GO:0060413Atrial septum morphogenesisIMPbiological_process
GO:0060577Pulmonary vein morphogenesisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75128180160.58598778920.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0048641675
GSE13712_SHEARUp0.0093739252
GSE13712_STATICDown-0.0641072033
GSE19018Down-0.1220837405
GSE19899_A1Up0.0379321529
GSE19899_A2Up0.0772330073
PubMed_21979375_A1Up0.1435921497
PubMed_21979375_A2Up0.3234174747
GSE35957Up0.1828756957
GSE36640Down-0.0981759686
GSE54402Up0.0243206449
GSE9593Up0.0185506901
GSE43922Up0.0214473926
GSE24585Down-0.2276721686
GSE37065Down-0.0643036238
GSE28863_A1Up0.0067663505
GSE28863_A2Down-0.1999230034
GSE28863_A3Up0.2824229829
GSE28863_A4Down-0.0433108386
GSE48662Down-0.0729111661

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22532803Epigenome-wide association scans (EWAS) identified age-related phenotype DMRs (ap-DMRs) associated with LDL (STAT5A), lung function (WT1), and maternal longevity (ARL4A, TBX20)
22532803In contrast, EWAS for chronological age identified hundreds of predominantly hyper-methylated age DMRs (490 a-DMRs at FDR 5%), of which only one (TBX20) was also associated with an age-related phenotype
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