HCSGD entry for AKR1B10
1. General information
| Official gene symbol | AKR1B10 |
|---|---|
| Entrez ID | 57016 |
| Gene full name | aldo-keto reductase family 1, member B10 (aldose reductase) |
| Other gene symbols | AKR1B11 AKR1B12 ALDRLn ARL-1 ARL1 HIS HSI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0001758 | Retinal dehydrogenase activity | IDA | molecular_function |
| GO:0004033 | Aldo-keto reductase (NADP) activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006081 | Cellular aldehyde metabolic process | TAS | biological_process |
| GO:0007586 | Digestion | TAS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0016488 | Farnesol catabolic process | IDA | biological_process |
| GO:0044597 | Daunorubicin metabolic process | IMP | biological_process |
| GO:0044598 | Doxorubicin metabolic process | IMP | biological_process |
| GO:0045550 | Geranylgeranyl reductase activity | IDA | molecular_function |
| GO:0047718 | Indanol dehydrogenase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0105086737 | 0.2928759660 | 0.2612508026 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.9512753293 |
| GSE13712_SHEAR | Down | -0.1387020739 |
| GSE13712_STATIC | Up | 0.0366607134 |
| GSE19018 | Up | 0.0320167973 |
| GSE19899_A1 | Up | 0.0453258683 |
| GSE19899_A2 | Down | -1.3025997312 |
| PubMed_21979375_A1 | Down | -0.3499898865 |
| PubMed_21979375_A2 | Down | -0.1534920456 |
| GSE35957 | Down | -0.0973226658 |
| GSE36640 | Up | 1.2543160039 |
| GSE54402 | Up | 0.1343767599 |
| GSE9593 | Up | 2.1786478174 |
| GSE43922 | Up | 0.0426979456 |
| GSE24585 | Up | 0.2754110340 |
| GSE37065 | Down | -0.0017506496 |
| GSE28863_A1 | Down | -0.3024185718 |
| GSE28863_A2 | Up | 0.3687184230 |
| GSE28863_A3 | Up | 0.6158016708 |
| GSE28863_A4 | Down | -0.0666458733 |
| GSE48662 | Down | -0.2387132492 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tolrestat | DB02383 | EXPT03082 |
| 2'-Monophosphoadenosine 5'-Diphosphoribose | DB03461 | EXPT02293 |
| 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID | DB08772 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021442 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT021503 | Reporter assay;Microarray | Functional MTI | 21351259 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027833 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
