HCSGD entry for PSMC2

1. General information

Official gene symbolPSMC2
Entrez ID5701
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 2
Other gene symbolsMSS1 Nbla10058 S7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexIDAcellular_component
GO:0000932Cytoplasmic mRNA processing bodyIEA ISScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006508ProteolysisIEAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008233Peptidase activityIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0022624Proteasome accessory complexIEA ISScellular_component
GO:0030163Protein catabolic processIEAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74818397100.08280308120.99999024730.5450012253

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3149913931
GSE13712_SHEARDown-0.0090158668
GSE13712_STATICUp0.3346487770
GSE19018Down-0.5065628871
GSE19899_A1Down-0.5713693777
GSE19899_A2Down-0.3196304716
PubMed_21979375_A1Down-1.3496594873
PubMed_21979375_A2Down-1.0232519109
GSE35957Up0.1838561801
GSE36640Up0.4635680581
GSE54402Down-0.0817563857
GSE9593Up0.3291360105
GSE43922Down-0.0086820320
GSE24585Down-0.0635208308
GSE37065Down-0.0061068229
GSE28863_A1Down-0.0705778474
GSE28863_A2Up0.2886993827
GSE28863_A3Down-0.2400123062
GSE28863_A4Up0.0394038273
GSE48662Down-0.3682815583

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031892ProteomicsFunctional MTI (Weak)18668040
hsa-miR-484MIMAT0002174MIRT041958CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.