HCSGD entry for PSMC1

1. General information

Official gene symbolPSMC1
Entrez ID5700
Gene full nameproteasome (prosome, macropain) 26S subunit, ATPase, 1
Other gene symbolsP26S4 S4 p56
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000502Proteasome complexNAScellular_component
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006508ProteolysisIEAbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0008233Peptidase activityIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016887ATPase activityISSmolecular_function
GO:0017111Nucleoside-triphosphatase activityIEAmolecular_function
GO:0022624Proteasome accessory complexIEA ISScellular_component
GO:0030163Protein catabolic processIEAbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48724482730.57344014290.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4771324525
GSE13712_SHEARDown-0.1401864053
GSE13712_STATICUp0.0571742184
GSE19018Up0.3759746106
GSE19899_A1Down-0.1053093926
GSE19899_A2Down-0.1642420901
PubMed_21979375_A1Up0.1063120945
PubMed_21979375_A2Down-0.2973112938
GSE35957Down-0.2184733644
GSE36640Down-0.0813711078
GSE54402Up0.3196237478
GSE9593Down-0.1417101672
GSE43922Down-0.1024611592
GSE24585Down-0.0826260842
GSE37065Down-0.0283211845
GSE28863_A1Up0.2689799643
GSE28863_A2Up0.0592103831
GSE28863_A3Up0.0842621824
GSE28863_A4Up0.0172506095
GSE48662Down-0.0872854870

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028792MicroarrayFunctional MTI (Weak)19088304
hsa-miR-342-5pMIMAT0004694MIRT038229CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051203CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.