HCSGD entry for CTNNBIP1
1. General information
| Official gene symbol | CTNNBIP1 |
|---|---|
| Entrez ID | 56998 |
| Gene full name | catenin, beta interacting protein 1 |
| Other gene symbols | ICAT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001658 | Branching involved in ureteric bud morphogenesis | IBA | biological_process |
| GO:0002528 | Regulation of vascular permeability involved in acute inflammatory response | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0008013 | Beta-catenin binding | IPI | molecular_function |
| GO:0009952 | Anterior/posterior pattern specification | IBA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030178 | Negative regulation of Wnt signaling pathway | IBA | biological_process |
| GO:0030877 | Beta-catenin destruction complex | IDA | cellular_component |
| GO:0032091 | Negative regulation of protein binding | IDA | biological_process |
| GO:0043392 | Negative regulation of DNA binding | IEA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IMP | biological_process |
| GO:0045657 | Positive regulation of monocyte differentiation | IMP | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IMP | biological_process |
| GO:0048662 | Negative regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0060633 | Negative regulation of transcription initiation from RNA polymerase II promoter | IEA | biological_process |
| GO:0070016 | Armadillo repeat domain binding | IPI | molecular_function |
| GO:0072201 | Negative regulation of mesenchymal cell proliferation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9516888112 | 0.0482436154 | 0.9999902473 | 0.4113701328 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3307470079 |
| GSE13712_SHEAR | Down | -0.3167583513 |
| GSE13712_STATIC | Down | -0.4332923149 |
| GSE19018 | Up | 0.1458539334 |
| GSE19899_A1 | Down | -0.2005398375 |
| GSE19899_A2 | Down | -0.7008129816 |
| PubMed_21979375_A1 | Down | -0.4935683916 |
| PubMed_21979375_A2 | Down | -0.7043654522 |
| GSE35957 | Down | -0.3468473134 |
| GSE36640 | Up | 0.0501516854 |
| GSE54402 | Down | -0.0971088171 |
| GSE9593 | Up | 0.0087769083 |
| GSE43922 | Up | 0.0392218011 |
| GSE24585 | Up | 0.1379083892 |
| GSE37065 | Down | -0.2806992619 |
| GSE28863_A1 | Down | -0.1815803391 |
| GSE28863_A2 | Up | 0.0023139647 |
| GSE28863_A3 | Up | 0.0986084403 |
| GSE28863_A4 | Up | 0.0503172019 |
| GSE48662 | Down | -0.0301558626 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | MIRT000097 | Luciferase reporter assay | Functional MTI | 23478036 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT007364 | Luciferase reporter assay | Functional MTI | 23554908 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT007364 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019224 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026964 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037541 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-200a-3p | MIMAT0000682 | 1 | hsa-miR-200a | {Western blot} | {overexpression by miRNA precursor transfection} | 19703993 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18178582 | Using cleavable ICAT quantitative mass spectrometry, the effect of IR on protein levels in either the wild type or p53(K317R) thymocytes was determined |
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