HCSGD entry for CHPT1
1. General information
| Official gene symbol | CHPT1 |
|---|---|
| Entrez ID | 56994 |
| Gene full name | choline phosphotransferase 1 |
| Other gene symbols | CPT CPT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0001558 | Regulation of cell growth | NAS | biological_process |
| GO:0004142 | Diacylglycerol cholinephosphotransferase activity | IDA TAS | molecular_function |
| GO:0006629 | Lipid metabolic process | TAS | biological_process |
| GO:0006644 | Phospholipid metabolic process | TAS | biological_process |
| GO:0006656 | Phosphatidylcholine biosynthetic process | IDA TAS | biological_process |
| GO:0006657 | CDP-choline pathway | NAS | biological_process |
| GO:0006663 | Platelet activating factor biosynthetic process | IDA | biological_process |
| GO:0008654 | Phospholipid biosynthetic process | IEA | biological_process |
| GO:0016020 | Membrane | IEA NAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016780 | Phosphotransferase activity, for other substituted phosphate groups | IEA | molecular_function |
| GO:0019992 | Diacylglycerol binding | NAS | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | NAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046474 | Glycerophospholipid biosynthetic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6952918848 | 0.0611885187 | 0.9999902473 | 0.4660135995 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1678511242 |
| GSE13712_SHEAR | Down | -0.5752444690 |
| GSE13712_STATIC | Down | -0.0348362136 |
| GSE19018 | Up | 0.0856745524 |
| GSE19899_A1 | Down | -0.4778021754 |
| GSE19899_A2 | Down | -0.3380023855 |
| PubMed_21979375_A1 | Down | -0.4972697342 |
| PubMed_21979375_A2 | Down | -0.5128173771 |
| GSE35957 | Up | 0.0682875697 |
| GSE36640 | Up | 0.1874346722 |
| GSE54402 | Down | -0.7476603084 |
| GSE9593 | Up | 0.2702931988 |
| GSE43922 | Down | -0.4810101452 |
| GSE24585 | Up | 0.6916451142 |
| GSE37065 | Up | 0.2355334899 |
| GSE28863_A1 | Up | 0.2206151033 |
| GSE28863_A2 | Up | 0.1363555550 |
| GSE28863_A3 | Down | -0.5693811441 |
| GSE28863_A4 | Up | 0.1524520463 |
| GSE48662 | Down | -0.2254248661 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019907 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024793 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026717 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031836 | Microarray | Functional MTI (Weak) | 21199864 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22178194 | Affymetrix gene array data showed NeuT-induced alterations in the transcription of many enzymes involved in lipid metabolism, several of which (ACSL3, CHPT1, PLD1, LIPG, MGLL, LDL and NPC1) could be confirmed by quantitative realtime PCR |
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