HCSGD entry for PSMB6

1. General information

Official gene symbolPSMB6
Entrez ID5694
Gene full nameproteasome (prosome, macropain) subunit, beta type, 6
Other gene symbolsDELTA LMPY Y
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004175Endopeptidase activityNASmolecular_function
GO:0004298Threonine-type endopeptidase activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexIEA ISScellular_component
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051603Proteolysis involved in cellular protein catabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.78117885340.05769630330.99999024730.4519691461

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.6175816427
GSE13712_SHEARDown-0.0996702035
GSE13712_STATICDown-0.0274232779
GSE19018Up0.3125916382
GSE19899_A1Down-0.0136657384
GSE19899_A2Up0.0998810493
PubMed_21979375_A1Down-0.4177499081
PubMed_21979375_A2Down-0.2294288271
GSE35957Down-0.3288501639
GSE36640Down-0.0595037913
GSE54402Up0.3311565329
GSE9593Down-0.3247272237
GSE43922Up0.0159918914
GSE24585Down-0.1597875088
GSE37065Down-0.4454122745
GSE28863_A1Down-0.6053991749
GSE28863_A2Down-0.8138764365
GSE28863_A3Down-0.1671335145
GSE28863_A4Up0.1680765870
GSE48662Down-0.2365456931

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDEDB08515 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-185-3pMIMAT0004611MIRT038619CLASHFunctional MTI (Weak)23622248
hsa-miR-107MIMAT0000104MIRT048307CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049356CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.