HCSGD entry for EXOSC5

1. General information

Official gene symbolEXOSC5
Entrez ID56915
Gene full nameexosome component 5
Other gene symbolsRRP41B RRP46 Rrp46p hRrp46p p12B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00001753'-5'-exoribonuclease activityNASmolecular_function
GO:0000178Exosome (RNase complex)IDAcellular_component
GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0003723RNA bindingIEAmolecular_function
GO:0004532Exoribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005730NucleolusNAScellular_component
GO:0005737CytoplasmNAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006364RRNA processingNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0035327Transcriptionally active chromatinIMPcellular_component
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayIMP TASbiological_process
GO:0045006DNA deaminationIDAbiological_process
GO:0051607Defense response to virusIMPbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisNASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisNASbiological_process
GO:0090503RNA phosphodiester bond hydrolysis, exonucleolyticNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36611387490.24307365980.99999024730.9491571280

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1551461587
GSE13712_SHEARUp0.1099297944
GSE13712_STATICUp0.3193162077
GSE19018Up0.0689799680
GSE19899_A1Up0.0853598595
GSE19899_A2Up0.3228929139
PubMed_21979375_A1Up0.0058217282
PubMed_21979375_A2Down-0.0132753106
GSE35957Down-0.4623771179
GSE36640Down-0.0429531734
GSE54402Up0.1991245241
GSE9593Down-0.0908537388
GSE43922Up0.1937761794
GSE24585Down-0.8259585167
GSE37065Down-0.1274981979
GSE28863_A1Down-0.2760613708
GSE28863_A2Down-0.0455581193
GSE28863_A3Down-0.1961848900
GSE28863_A4Down-0.0687088514
GSE48662Up0.2327434083

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-31-5pMIMAT0000089MIRT049878CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.