HCSGD entry for SPHK2
1. General information
| Official gene symbol | SPHK2 |
|---|---|
| Entrez ID | 56848 |
| Gene full name | sphingosine kinase 2 |
| Other gene symbols | SK 2 SK-2 SPK 2 SPK-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001568 | Blood vessel development | IEA | biological_process |
| GO:0003951 | NAD+ kinase activity | IEA | molecular_function |
| GO:0004143 | Diacylglycerol kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA IEA TAS | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | TAS | biological_process |
| GO:0006669 | Sphinganine-1-phosphate biosynthetic process | NAS | biological_process |
| GO:0006670 | Sphingosine metabolic process | IEA | biological_process |
| GO:0007205 | Protein kinase C-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008481 | Sphinganine kinase activity | NAS | molecular_function |
| GO:0016020 | Membrane | IDA IEA | cellular_component |
| GO:0017016 | Ras GTPase binding | NAS | molecular_function |
| GO:0017050 | D-erythro-sphingosine kinase activity | IEA | molecular_function |
| GO:0030148 | Sphingolipid biosynthetic process | TAS | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | NAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046834 | Lipid phosphorylation | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3906722047 | 0.8859566354 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0878255560 |
| GSE13712_SHEAR | Down | -0.1312109098 |
| GSE13712_STATIC | Down | -0.3030955513 |
| GSE19018 | Down | -0.0109753526 |
| GSE19899_A1 | Down | -0.0998155704 |
| GSE19899_A2 | Up | 0.0977363038 |
| PubMed_21979375_A1 | Down | -0.1900909747 |
| PubMed_21979375_A2 | Up | 0.6150847058 |
| GSE35957 | Up | 0.2054153804 |
| GSE36640 | Up | 0.3620728185 |
| GSE54402 | Up | 0.1981408847 |
| GSE9593 | Up | 0.1976594822 |
| GSE43922 | Up | 0.0553307323 |
| GSE24585 | Down | -0.0413517248 |
| GSE37065 | Down | -0.0444403157 |
| GSE28863_A1 | Down | -0.0882917055 |
| GSE28863_A2 | Down | -0.1626685749 |
| GSE28863_A3 | Up | 0.1955213732 |
| GSE28863_A4 | Up | 0.1058524186 |
| GSE48662 | Up | 0.1911572798 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-149-5p | MIMAT0000450 | MIRT045673 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
