HCSGD entry for B2M

1. General information

Official gene symbolB2M
Entrez ID567
Gene full namebeta-2-microglobulin
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0001916Positive regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002237Response to molecule of bacterial originIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class IIEA TASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0002480Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTASbiological_process
GO:0002481Antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006955Immune responseIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016032Viral processTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0031901Early endosome membraneTAScellular_component
GO:0031905Early endosome lumenTAScellular_component
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0042026Protein refoldingIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042612MHC class I protein complexIEAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0046686Response to cadmium ionIEAbiological_process
GO:0050690Regulation of defense response to virus by virusTASbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.18651196380.79156133890.84248865631.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0437394742
GSE13712_SHEARUp0.2866188058
GSE13712_STATICUp0.1809089018
GSE19018Up0.2509678765
GSE19899_A1Down-0.0320450742
GSE19899_A2Down-0.0854866343
PubMed_21979375_A1Down-0.3470975064
PubMed_21979375_A2Up0.0571316203
GSE35957Up0.0501174945
GSE36640Up0.4795635872
GSE54402Up0.0780789046
GSE9593Down-0.0313599308
GSE43922Down-0.2445428593
GSE24585Up0.4580703299
GSE37065Up0.4712067386
GSE28863_A1Up0.2172968416
GSE28863_A2Up0.3764283613
GSE28863_A3Down-0.2853713278
GSE28863_A4Up0.2208528827
GSE48662Down-0.6921913747

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3-Indolebutyric AcidDB02740 EXPT00173
N-FormylmethionineDB04464 EXPT01455

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-5pMIMAT0000093MIRT028088SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18592462Specific primers for BMI1 and B2M (as an internal control) were used for reverse transcript polymerase chain reaction technique
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