HCSGD entry for PSAP
1. General information
| Official gene symbol | PSAP |
|---|---|
| Entrez ID | 5660 |
| Gene full name | prosaposin |
| Other gene symbols | GLBA SAP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA ISS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0005765 | Lysosomal membrane | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006665 | Sphingolipid metabolic process | IEA TAS | biological_process |
| GO:0006687 | Glycosphingolipid metabolic process | TAS | biological_process |
| GO:0006869 | Lipid transport | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008047 | Enzyme activator activity | TAS | molecular_function |
| GO:0008289 | Lipid binding | TAS | molecular_function |
| GO:0016021 | Integral component of membrane | TAS | cellular_component |
| GO:0019216 | Regulation of lipid metabolic process | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043408 | Regulation of MAPK cascade | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0060736 | Prostate gland growth | IEA | biological_process |
| GO:0060742 | Epithelial cell differentiation involved in prostate gland development | IEA | biological_process |
| GO:0071310 | Cellular response to organic substance | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0013158505 | 0.9982977243 | 0.0983934659 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7386401854 |
| GSE13712_SHEAR | Up | 0.0304907266 |
| GSE13712_STATIC | Up | 0.1398692467 |
| GSE19018 | Up | 0.3215920967 |
| GSE19899_A1 | Up | 1.4004895233 |
| GSE19899_A2 | Up | 1.1528910265 |
| PubMed_21979375_A1 | Up | 1.1164715287 |
| PubMed_21979375_A2 | Up | 0.6674149486 |
| GSE35957 | Up | 0.1857849712 |
| GSE36640 | Up | 1.2632107082 |
| GSE54402 | Up | 0.3304767555 |
| GSE9593 | Up | 0.8585080718 |
| GSE43922 | Up | 0.7044480462 |
| GSE24585 | Up | 0.1315692802 |
| GSE37065 | Up | 0.2716098548 |
| GSE28863_A1 | Up | 0.3138918924 |
| GSE28863_A2 | Up | 0.4838599332 |
| GSE28863_A3 | Down | -0.0446341416 |
| GSE28863_A4 | Down | -0.0541188857 |
| GSE48662 | Up | 0.4247950018 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Di-Stearoyl-3-Sn-Phosphatidylethanolamine | DB01966 | EXPT02546 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-19a-3p | MIMAT0000073 | MIRT007122 | Luciferase reporter assay | Functional MTI | 23451058 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018440 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020333 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031264 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040177 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042740 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042859 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045562 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-191-5p | MIMAT0000440 | MIRT045804 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046360 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050439 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19471889 | Exploration of senescence-associated genes by differential display reverse transcription polymerase chain reaction: prosaposin as a novel senescence-associated gene |
| 19471889 | Among these DEGs, the level of prosaposin mRNA was elevated of in senescent human dermal fibroblast (HDF) and human umbilical vein endothelial cells (HUVECs) |
| 19471889 | It was further confirmed that expression of prosaposin was up-regulated in prematurely senescent HUVECs induced by hydrogen peroxide or interferon-gamma treatment |
| 19471889 | Taken together, we report the up-regulation of prosaposin in the senescent HDF and HUVECs as well as in hydrogen peroxide or interferon-gamma induced prematurely senescent HUVECs, suggesting that prosaposin might be a novel senescence-associated gene |
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