HCSGD entry for KLK10
1. General information
| Official gene symbol | KLK10 |
|---|---|
| Entrez ID | 5655 |
| Gene full name | kallikrein-related peptidase 10 |
| Other gene symbols | NES1 PRSSL1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3167986779 | 0.9059359219 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0455069721 |
| GSE13712_SHEAR | Up | 0.0166454281 |
| GSE13712_STATIC | Up | 0.0793191343 |
| GSE19018 | Up | 0.0669953856 |
| GSE19899_A1 | Up | 0.1378879628 |
| GSE19899_A2 | Up | 0.0315250485 |
| PubMed_21979375_A1 | Down | -0.1082168626 |
| PubMed_21979375_A2 | Up | 0.1811828625 |
| GSE35957 | Up | 0.0047826970 |
| GSE36640 | Down | -0.0561993825 |
| GSE54402 | Up | 0.0700025757 |
| GSE9593 | Up | 0.2162332619 |
| GSE43922 | Up | 0.0785556727 |
| GSE24585 | Up | 0.1553358188 |
| GSE37065 | Up | 0.6280744199 |
| GSE28863_A1 | Down | -0.1630058104 |
| GSE28863_A2 | Down | -0.1523037230 |
| GSE28863_A3 | Up | 0.3110983390 |
| GSE28863_A4 | Up | 0.0851445201 |
| GSE48662 | Up | 0.1849269792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-224-5p | MIMAT0000281 | MIRT000454 | qRT-PCR//Luciferase reporter assay | Functional MTI | 20354523 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT000455 | qRT-PCR//Luciferase reporter assay | Functional MTI | 20354523 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT000455 | ELISA//Luciferase reporter assay//qRT-PCR | Functional MTI | 18627289 |
| hsa-miR-375 | MIMAT0000728 | MIRT019672 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7f-5p | MIMAT0000067 | NA | hsa-let-7f | {Western blot} | {overexpression by miRNA precursor transfection} | 20354523 | |
| hsa-miR-224-5p | MIMAT0000281 | NA | hsa-miR-224 | {Western blot} | {overexpression by miRNA precursor transfection} | 20354523 | |
| hsa-miR-516a-5p | MIMAT0004770 | NA | hsa-miR-516a-5p | {Western blot} | {overexpression by miRNA precursor transfection} | 20354523 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
