HCSGD entry for HTRA1
1. General information
| Official gene symbol | HTRA1 |
|---|---|
| Entrez ID | 5654 |
| Gene full name | HtrA serine peptidase 1 |
| Other gene symbols | ARMD7 CARASIL HtrA L56 ORF480 PRSS11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | IEA | biological_process |
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005520 | Insulin-like growth factor binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA ISS | biological_process |
| GO:0008236 | Serine-type peptidase activity | ISS | molecular_function |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IEA | biological_process |
| GO:0030514 | Negative regulation of BMP signaling pathway | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8382847308 | 0.0139826564 | 0.9999902473 | 0.2324936829 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9081004721 |
| GSE13712_SHEAR | Down | -1.7289513728 |
| GSE13712_STATIC | Down | -0.7994925729 |
| GSE19018 | Down | -0.0217127402 |
| GSE19899_A1 | Down | -0.9658164249 |
| GSE19899_A2 | Down | -0.1697896596 |
| PubMed_21979375_A1 | Down | -1.2728990382 |
| PubMed_21979375_A2 | Up | 0.1101592908 |
| GSE35957 | Down | -0.3409666019 |
| GSE36640 | Up | 0.0328380713 |
| GSE54402 | Down | -0.2249698821 |
| GSE9593 | Up | 0.1835634269 |
| GSE43922 | Down | -0.4733726863 |
| GSE24585 | Down | -0.3055086327 |
| GSE37065 | Down | -0.2401685295 |
| GSE28863_A1 | Up | 0.0265202529 |
| GSE28863_A2 | Up | 0.0366424735 |
| GSE28863_A3 | Up | 0.2024899362 |
| GSE28863_A4 | Down | -0.1545697669 |
| GSE48662 | Up | 0.0904786995 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT021015 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030211 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032028 | Proteomics | Functional MTI (Weak) | 18668040 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23623979 | In this study, we examine the role of HtrA1 in premature senescence and cell death induced by oxidative stress |
| 23623979 | HtrA1 mRNA and protein were up-regulated during premature senescence induced by H2O2 in both mouse embryonic fibroblasts (MEFs) and ARPE-19 cells |
| 23623979 | Expression of the senescence markers p21(CIP1/WAF1) and p16(INK4a), and SA-beta-galactosidase activity, were higher in HtrA1+/- MEFs than in HtrA1-/- MEFs |
| 23623979 | HtrA1+/+ and HtrA1+/- MEFs were more resistant than HtrA1-/- MEFs to H2O2-induced cell death |
| 23623979 | The effects of excess HtrA1 were examined by transient transfection of cells with HtrA1 expression vectors or by addition of recombinant proteins |
| 23623979 | Excess wild type HtrA1 accelerated premature senescence of MEFs and ARPE-19 cells, while the protease-inactive HtrA1 S328A did not |
Entries Per Page
Displaying Page of
