HCSGD entry for PRSS2

1. General information

Official gene symbolPRSS2
Entrez ID5645
Gene full nameprotease, serine, 2 (trypsin 2)
Other gene symbolsTRY2 TRY8 TRYP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004252Serine-type endopeptidase activityIDAmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIMPcellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0007586DigestionIEAbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030307Positive regulation of cell growthTASbiological_process
GO:0030574Collagen catabolic processIDA IMP TASbiological_process
GO:0031012Extracellular matrixTAScellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0045785Positive regulation of cell adhesionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00013304210.99776886900.03367115381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.9558450179
GSE13712_SHEARUp1.0936746981
GSE13712_STATICUp0.7891722982
GSE19018Up0.1465256224
GSE19899_A1Up0.7504805402
GSE19899_A2Up1.4961529568
PubMed_21979375_A1Up3.7525312091
PubMed_21979375_A2Up2.0331337212
GSE35957Up0.2350601392
GSE36640Up0.3095653850
GSE54402Up2.9704835182
GSE9593Up0.1684224593
GSE43922Up1.2694656489
GSE24585Up0.2971683523
GSE37065Up0.1450035061
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1385859496

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MonoisopropylphosphorylserineDB01805 EXPT02178
O-Benzylsulfonyl-SerineDB01973 EXPT02878
Isopropyl AlcoholDB02325 EXPT01912 | DB04402
BenzylamineDB02464 EXPT00400
BenzamidineDB03127 EXPT00669
PhosphorylisopropaneDB03976 EXPT01937
2-PhenylethylamineDB04325 EXPT02542
3-PhenylpropylamineDB04410 EXPT02655

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.