HCSGD entry for LGMN
1. General information
| Official gene symbol | LGMN |
|---|---|
| Entrez ID | 5641 |
| Gene full name | legumain |
| Other gene symbols | AEP LGMN1 PRSC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001101 | Response to acid | IEA | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0003014 | Renal system process | ISS | biological_process |
| GO:0004197 | Cysteine-type endopeptidase activity | IEA ISS | molecular_function |
| GO:0005764 | Lysosome | ISS | cellular_component |
| GO:0005770 | Late endosome | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA ISS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0008233 | Peptidase activity | IDA | molecular_function |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0032801 | Receptor catabolic process | ISS | biological_process |
| GO:0040015 | Negative regulation of multicellular organism growth | IEA | biological_process |
| GO:0042359 | Vitamin D metabolic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0043524 | Negative regulation of neuron apoptotic process | IGI | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045177 | Apical part of cell | IEA | cellular_component |
| GO:0051603 | Proteolysis involved in cellular protein catabolic process | ISS | biological_process |
| GO:1901185 | Negative regulation of ERBB signaling pathway | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0204748528 | 0.7745388055 | 0.3439174218 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0237940101 |
| GSE13712_SHEAR | Up | 0.1188557068 |
| GSE13712_STATIC | Up | 0.3908966891 |
| GSE19018 | Up | 0.5351600206 |
| GSE19899_A1 | Down | -0.3245110650 |
| GSE19899_A2 | Up | 0.5547219746 |
| PubMed_21979375_A1 | Down | -1.0635583416 |
| PubMed_21979375_A2 | Down | -0.4908232957 |
| GSE35957 | Up | 0.1574253889 |
| GSE36640 | Up | 1.7105798719 |
| GSE54402 | Up | 0.0167476884 |
| GSE9593 | Up | 0.9552534756 |
| GSE43922 | Down | -0.1936462483 |
| GSE24585 | Up | 0.5779093571 |
| GSE37065 | Up | 0.2777111623 |
| GSE28863_A1 | Up | 0.2557263783 |
| GSE28863_A2 | Up | 0.0926483417 |
| GSE28863_A3 | Up | 0.3263091412 |
| GSE28863_A4 | Up | 0.0474463913 |
| GSE48662 | Up | 0.2483717572 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024860 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026385 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029310 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-642a-5p | MIMAT0003312 | MIRT039572 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
