HCSGD entry for METTL3
1. General information
| Official gene symbol | METTL3 |
|---|---|
| Entrez ID | 56339 |
| Gene full name | methyltransferase like 3 |
| Other gene symbols | IME4 M6A MT-A70 Spo8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001510 | RNA methylation | IMP | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006397 | MRNA processing | ISS | biological_process |
| GO:0007623 | Circadian rhythm | ISS | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016422 | MRNA (2'-O-methyladenosine-N6-)-methyltransferase activity | IEA IMP | molecular_function |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0080009 | MRNA methylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6574549447 | 0.2784611489 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1956210572 |
| GSE13712_SHEAR | Up | 0.1524694561 |
| GSE13712_STATIC | Up | 0.0850518182 |
| GSE19018 | Down | -0.1959867511 |
| GSE19899_A1 | Up | 0.2524847640 |
| GSE19899_A2 | Down | -0.0396490445 |
| PubMed_21979375_A1 | Down | -0.2557831479 |
| PubMed_21979375_A2 | Down | -0.0710212092 |
| GSE35957 | Down | -0.5271768694 |
| GSE36640 | Up | 0.3140254384 |
| GSE54402 | Down | -0.1795604032 |
| GSE9593 | Down | -0.4476300160 |
| GSE43922 | Up | 0.0625658969 |
| GSE24585 | Down | -0.1711732045 |
| GSE37065 | Down | -0.2229892265 |
| GSE28863_A1 | Down | -0.0092358902 |
| GSE28863_A2 | Up | 0.1580504311 |
| GSE28863_A3 | Down | -0.2554704639 |
| GSE28863_A4 | Up | 0.0510392661 |
| GSE48662 | Up | 0.0020341803 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
