HCSGD entry for PARD3

1. General information

Official gene symbolPARD3
Entrez ID56288
Gene full namepar-3 partitioning defective 3 homolog (C. elegans)
Other gene symbolsASIP Baz PAR3 PAR3alpha PARD-3 PARD3A SE2-5L16 SE2-5LT1 SE2-5T2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0003383Apical constrictionIEAbiological_process
GO:0005080Protein kinase C bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005546Phosphatidylinositol-4,5-bisphosphate bindingISSmolecular_function
GO:0005547Phosphatidylinositol-3,4,5-trisphosphate bindingISSmolecular_function
GO:0005819SpindleIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDA ISScellular_component
GO:0005913Cell-cell adherens junctionIEAcellular_component
GO:0005923Tight junctionIDA ISScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0006612Protein targeting to membraneISSbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007163Establishment or maintenance of cell polarityTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007409AxonogenesisTASbiological_process
GO:0008356Asymmetric cell divisionTASbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0030054Cell junctionTAScellular_component
GO:0032266Phosphatidylinositol-3-phosphate bindingISSmolecular_function
GO:0032970Regulation of actin filament-based processIEAbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0044295Axonal growth coneIEAcellular_component
GO:0044319Wound healing, spreading of cellsIEAbiological_process
GO:0045177Apical part of cellIEAcellular_component
GO:0045216Cell-cell junction organizationTASbiological_process
GO:0051642Centrosome localizationIEAbiological_process
GO:0060341Regulation of cellular localizationIEAbiological_process
GO:0070830Tight junction assemblyISS TASbiological_process
GO:0090162Establishment of epithelial cell polarityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13555820070.95680168690.74349393621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2474333040
GSE13712_SHEARUp0.1472864322
GSE13712_STATICUp0.2105719432
GSE19018Up0.1660309266
GSE19899_A1Up0.0802367728
GSE19899_A2Up0.2900945406
PubMed_21979375_A1Up0.3449890754
PubMed_21979375_A2Up0.3969562484
GSE35957Down-0.1445768592
GSE36640Down-0.1053463568
GSE54402Up0.1694505524
GSE9593Up0.2769281265
GSE43922Up0.0472927276
GSE24585Down-0.0452922755
GSE37065Up0.0294078239
GSE28863_A1Up0.3743597126
GSE28863_A2Up0.3588174743
GSE28863_A3Down-0.3598886738
GSE28863_A4Up0.0358682911
GSE48662Down-0.0687886398

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-483-3pMIMAT0002173MIRT006686qRT-PCR//Western blotFunctional MTI22101077
hsa-miR-93-3pMIMAT0004509MIRT038900CLASHFunctional MTI (Weak)23622248
hsa-miR-766-3pMIMAT0003888MIRT039030CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.