HCSGD entry for PROS1
1. General information
| Official gene symbol | PROS1 |
|---|---|
| Entrez ID | 5627 |
| Gene full name | protein S (alpha) |
| Other gene symbols | PROS PS21 PS22 PS23 PS24 PS25 PSA THPH5 THPH6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA NAS TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0006508 | Proteolysis | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0010466 | Negative regulation of peptidase activity | TAS | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0017187 | Peptidyl-glutamic acid carboxylation | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0042730 | Fibrinolysis | IEA | biological_process |
| GO:0043086 | Negative regulation of catalytic activity | TAS | biological_process |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0052547 | Regulation of peptidase activity | TAS | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0238427073 | 0.0218420995 | 0.3662102100 | 0.2849011397 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4243456346 |
| GSE13712_SHEAR | Down | -2.0045079759 |
| GSE13712_STATIC | Down | -1.0545954362 |
| GSE19018 | Down | -2.9303367876 |
| GSE19899_A1 | Up | 0.2459279894 |
| GSE19899_A2 | Down | -0.7244541483 |
| PubMed_21979375_A1 | Down | -0.4303143749 |
| PubMed_21979375_A2 | Up | 1.1108769481 |
| GSE35957 | Up | 0.2853442691 |
| GSE36640 | Up | 3.5942154336 |
| GSE54402 | Down | -0.9247569564 |
| GSE9593 | Up | 1.0853026096 |
| GSE43922 | Down | -0.0288771707 |
| GSE24585 | Up | 0.4513336131 |
| GSE37065 | Down | -0.1033538637 |
| GSE28863_A1 | Up | 0.2858437274 |
| GSE28863_A2 | Up | 0.6642645397 |
| GSE28863_A3 | Down | -0.2272830052 |
| GSE28863_A4 | Up | 0.0448192384 |
| GSE48662 | Up | 0.0195214728 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Menadione | DB00170 | NUTR00062 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018834 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
