HCSGD entry for CCBL2
1. General information
| Official gene symbol | CCBL2 |
|---|---|
| Entrez ID | 56267 |
| Gene full name | cysteine conjugate-beta lyase 2 |
| Other gene symbols | KAT3 KATIII RP4-531M19.2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0006103 | 2-oxoglutarate metabolic process | IEA | biological_process |
| GO:0006520 | Cellular amino acid metabolic process | ISS | biological_process |
| GO:0006569 | Tryptophan catabolic process | TAS | biological_process |
| GO:0009058 | Biosynthetic process | IEA | biological_process |
| GO:0016212 | Kynurenine-oxoglutarate transaminase activity | ISS | molecular_function |
| GO:0030170 | Pyridoxal phosphate binding | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047315 | Kynurenine-glyoxylate transaminase activity | ISS | molecular_function |
| GO:0047804 | Cysteine-S-conjugate beta-lyase activity | IEA | molecular_function |
| GO:0070189 | Kynurenine metabolic process | ISS | biological_process |
| GO:0097052 | L-kynurenine metabolic process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8694934995 | 0.0852976217 | 0.9999902473 | 0.5542134535 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2399183334 |
| GSE13712_SHEAR | Down | -0.0068687381 |
| GSE13712_STATIC | Up | 0.1879896518 |
| GSE19018 | Up | 0.3525505553 |
| GSE19899_A1 | Down | -0.8157942058 |
| GSE19899_A2 | Down | -0.2198196609 |
| PubMed_21979375_A1 | Down | -0.6160124535 |
| PubMed_21979375_A2 | Down | -0.5347407029 |
| GSE35957 | Down | -0.1714754749 |
| GSE36640 | Down | -0.3964930257 |
| GSE54402 | Down | -0.0395921034 |
| GSE9593 | Down | -0.1137412051 |
| GSE43922 | Down | -0.4636222201 |
| GSE24585 | Up | 0.2305179387 |
| GSE37065 | Up | 0.2249182442 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.5916506576 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005220 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019587 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022902 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
