HCSGD entry for PRODH

1. General information

Official gene symbolPRODH
Entrez ID5625
Gene full nameproline dehydrogenase (oxidase) 1
Other gene symbolsHSPOX2 PIG6 POX PRODH1 PRODH2 TP53I6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004657Proline dehydrogenase activityIDA IEAmolecular_function
GO:0005743Mitochondrial inner membraneIEA TAScellular_component
GO:0005759Mitochondrial matrixIEAcellular_component
GO:0006537Glutamate biosynthetic processIEAbiological_process
GO:0006560Proline metabolic processTASbiological_process
GO:0006562Proline catabolic processIEA TASbiological_process
GO:0008631Intrinsic apoptotic signaling pathway in response to oxidative stressNASbiological_process
GO:0010133Proline catabolic process to glutamateIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:00194704-hydroxyproline catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0071949FAD bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.89428596560.78808049850.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0926555199
GSE28863_A2Down-0.1397479513
GSE28863_A3Up0.3285577490
GSE28863_A4Up0.0254918471
GSE48662Down-0.0592880601

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-5pMIMAT0004587MIRT004581Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20562915
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.