HCSGD entry for EIF2AK2

1. General information

Official gene symbolEIF2AK2
Entrez ID5610
Gene full nameeukaryotic translation initiation factor 2-alpha kinase 2
Other gene symbolsEIF2AK1 PKR PRKR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityIMPbiological_process
GO:0001819Positive regulation of cytokine productionISSbiological_process
GO:0003725Double-stranded RNA bindingIDA IEAmolecular_function
GO:0004672Protein kinase activityIDA IEA IMPmolecular_function
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0004694Eukaryotic translation initiation factor 2alpha kinase activityTASmolecular_function
GO:0004715Non-membrane spanning protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006412TranslationIEAbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0008601Protein phosphatase type 2A regulator activityTASmolecular_function
GO:0009615Response to virusIMPbiological_process
GO:0017148Negative regulation of translationIDA IMPbiological_process
GO:0019048Modulation by virus of host morphology or physiologyTASbiological_process
GO:0019054Modulation by virus of host processTASbiological_process
GO:0019058Viral life cycleTASbiological_process
GO:0030683Evasion or tolerance by virus of host immune responseTASbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseIEAbiological_process
GO:0032722Positive regulation of chemokine productionIEA ISSbiological_process
GO:0032874Positive regulation of stress-activated MAPK cascadeIEA ISSbiological_process
GO:0033689Negative regulation of osteoblast proliferationIMPbiological_process
GO:0035455Response to interferon-alphaIDAbiological_process
GO:0045071Negative regulation of viral genome replicationIEA IMPbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0046777Protein autophosphorylationIDA IEA IMPbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051607Defense response to virusIEAbiological_process
GO:1900225Regulation of NLRP3 inflammasome complex assemblyIEA ISSbiological_process
GO:1901224Positive regulation of NIK/NF-kappaB signalingIEA ISSbiological_process
GO:1901532Regulation of hematopoietic progenitor cell differentiationISSbiological_process
GO:1902033Regulation of hematopoietic stem cell proliferationIEA ISSbiological_process
GO:1902036Regulation of hematopoietic stem cell differentiationIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12106898670.18929908820.71146613080.8433549932

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0959576548
GSE13712_SHEARUp0.9973215541
GSE13712_STATICUp0.5357554556
GSE19018Up0.1095139653
GSE19899_A1Down-0.1044794668
GSE19899_A2Down-0.2581986613
PubMed_21979375_A1Down-0.7073770330
PubMed_21979375_A2Down-0.2944864724
GSE35957Down-0.9189462033
GSE36640Up0.1136682079
GSE54402Down-0.1531571838
GSE9593Up0.2517644355
GSE43922Down-0.0758429222
GSE24585Down-0.1927024486
GSE37065Up0.5344934428
GSE28863_A1Up0.4332757521
GSE28863_A2Up1.5729865693
GSE28863_A3Down-0.0777122976
GSE28863_A4Down-0.3859874922
GSE48662Up0.3286653322

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019974qRT-PCR;MicroarrayFunctional MTI (Weak)20584986
hsa-miR-124-3pMIMAT0000422MIRT022755ProteomicsFunctional MTI (Weak)18668037
hsa-miR-877-5pMIMAT0004949MIRT037216CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046386CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.