HCSGD entry for MAP2K1
1. General information
| Official gene symbol | MAP2K1 |
|---|---|
| Entrez ID | 5604 |
| Gene full name | mitogen-activated protein kinase kinase 1 |
| Other gene symbols | MAPKK1 MEK1 MKK1 PRKMK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0000186 | Activation of MAPKK activity | TAS | biological_process |
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0003056 | Regulation of vascular smooth muscle contraction | IEA | biological_process |
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0004708 | MAP kinase kinase activity | IDA | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | TAS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004728 | Receptor signaling protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | TAS | cellular_component |
| GO:0005769 | Early endosome | TAS | cellular_component |
| GO:0005770 | Late endosome | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0005816 | Spindle pole body | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005925 | Focal adhesion | TAS | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006979 | Response to oxidative stress | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | IMP | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0017016 | Ras GTPase binding | IEA | molecular_function |
| GO:0030216 | Keratinocyte differentiation | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IEA | biological_process |
| GO:0031435 | Mitogen-activated protein kinase kinase kinase binding | IEA | molecular_function |
| GO:0032320 | Positive regulation of Ras GTPase activity | IEA | biological_process |
| GO:0032402 | Melanosome transport | IEA | biological_process |
| GO:0032839 | Dendrite cytoplasm | IEA | cellular_component |
| GO:0032872 | Regulation of stress-activated MAPK cascade | TAS | biological_process |
| GO:0032968 | Positive regulation of transcription elongation from RNA polymerase II promoter | IEA | biological_process |
| GO:0034111 | Negative regulation of homotypic cell-cell adhesion | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0043204 | Perikaryon | IEA | cellular_component |
| GO:0043539 | Protein serine/threonine kinase activator activity | IDA | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045597 | Positive regulation of cell differentiation | IEA | biological_process |
| GO:0046579 | Positive regulation of Ras protein signal transduction | IEA | biological_process |
| GO:0047496 | Vesicle transport along microtubule | IEA | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048313 | Golgi inheritance | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048678 | Response to axon injury | IEA | biological_process |
| GO:0048870 | Cell motility | IEA | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0060674 | Placenta blood vessel development | IEA | biological_process |
| GO:0060711 | Labyrinthine layer development | IEA | biological_process |
| GO:0071902 | Positive regulation of protein serine/threonine kinase activity | IDA | biological_process |
| GO:0090170 | Regulation of Golgi inheritance | TAS | biological_process |
| GO:0090398 | Cellular senescence | IMP | biological_process |
| GO:2000641 | Regulation of early endosome to late endosome transport | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0267862733 | 0.9777523042 | 0.3813096268 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0840264362 |
| GSE13712_SHEAR | Up | 0.4928510587 |
| GSE13712_STATIC | Up | 0.1680856432 |
| GSE19018 | Up | 0.7208129427 |
| GSE19899_A1 | Up | 0.2432368063 |
| GSE19899_A2 | Up | 0.4145489504 |
| PubMed_21979375_A1 | Up | 0.7439834800 |
| PubMed_21979375_A2 | Up | 0.3270210031 |
| GSE35957 | Up | 0.1232213897 |
| GSE36640 | Down | -0.2576910739 |
| GSE54402 | Up | 0.4271373494 |
| GSE9593 | Up | 0.4740275937 |
| GSE43922 | Up | 0.1398134300 |
| GSE24585 | Up | 0.2863148430 |
| GSE37065 | Up | 0.3056112215 |
| GSE28863_A1 | Down | -0.0223878077 |
| GSE28863_A2 | Up | 0.1637470263 |
| GSE28863_A3 | Down | -0.2416133583 |
| GSE28863_A4 | Down | -0.1570859513 |
| GSE48662 | Down | -0.0210264301 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| K-252a | DB02152 | EXPT01983 |
| 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide | DB03115 | EXPT00634 |
| Cobimetinib | DB05239 | - |
| Bosutinib | DB06616 | - |
| (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide | DB06892 | - |
| 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide | DB07046 | - |
| N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide | DB07101 | - |
| N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine | DB08130 | - |
| 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE | DB08208 | - |
| Trametinib | DB08911 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-424-5p | MIMAT0001341 | MIRT003226 | Luciferase reporter assay | Functional MTI | 20065103 |
| hsa-miR-424-5p | MIMAT0001341 | MIRT003226 | Immunohistochemistry//qRT-PCR//Western blot | Functional MTI | 21179471 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT004483 | qRT-PCR//Luciferase reporter assay//Western blot//Northern blot | Functional MTI | 20299489 |
| hsa-miR-497-5p | MIMAT0002820 | MIRT007165 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23092882 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022002 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025120 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027265 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038788 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047918 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | 1 | hsa-miR-34a | {Western blot} | {overexpression by miRNA precursor transfection} | 20299489 | |
| hsa-miR-424-5p | MIMAT0001341 | NA | hsa-miR-424 | 20065103 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22359342 | We demonstrate here that oncogenic K-RAS induces PML protein upregulation by activating the RAS/MEK1/mTOR/eIF4E pathway even in the absence of p53 |
| 19342460 | Unexpectedly, these changes were independent of changes in proliferation rate within the hyperplastic tissue, suggesting that endogenous SST controls GHRH-induced adenoma formation primarily via modulation of apoptotic and/or cellular senescence pathways, consistent with the predicted function of some of the most differentially expressed genes (Casp1, MAP2K1, TNFR2) identified by membrane arrays and confirmed by quantitative real-time RT-PCR |
| 16672767 | CRE-dependent luciferase activation was abrogated in the presence of inhibitors of PKC, MEK1, p38MAPK, and PKA, in both young and senescent HDFs |
| 9426047 | A second inhibitor, PD58029, which is specific for the mitogen-activated protein kinase kinase 1 (MEK-1), also induces a growth arrest but does not induce the same spectrum of gene expression |
| 9426047 | The pattern of gene expression in the presence the MEK-1 inhibitor is similar to that seen during growth arrest induced by serum starvation |
| 9426047 | Thus, growth arrest with a PI-3 kinase inhibitor induces a senescent-like phenotype that is not seen when cells are growth arrested by either serum starvation or a MEK-1 inhibitor |
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