HCSGD entry for MAPK10
1. General information
| Official gene symbol | MAPK10 |
|---|---|
| Entrez ID | 5602 |
| Gene full name | mitogen-activated protein kinase 10 |
| Other gene symbols | JNK3 JNK3A PRKM10 SAPK1b p493F12 p54bSAPK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004705 | JUN kinase activity | ISS | molecular_function |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0004708 | MAP kinase kinase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005739 | Mitochondrion | IEA ISS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA ISS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007254 | JNK cascade | ISS TAS | biological_process |
| GO:0007258 | JUN phosphorylation | ISS TAS | biological_process |
| GO:0016772 | Transferase activity, transferring phosphorus-containing groups | IEA | molecular_function |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0051090 | Regulation of sequence-specific DNA binding transcription factor activity | TAS | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4541401618 | 0.2095464648 | 0.9999902473 | 0.8847579926 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0225236785 |
| GSE13712_SHEAR | Down | -0.0294579615 |
| GSE13712_STATIC | Down | -0.0142263349 |
| GSE19018 | Down | -0.1593859404 |
| GSE19899_A1 | Up | 0.2160310599 |
| GSE19899_A2 | Down | -0.4636593120 |
| PubMed_21979375_A1 | Down | -0.2443941902 |
| PubMed_21979375_A2 | Down | -0.0301293926 |
| GSE35957 | Up | 0.2499388512 |
| GSE36640 | Up | 0.4514836746 |
| GSE54402 | Down | -0.0746965667 |
| GSE9593 | Down | -0.2503327459 |
| GSE43922 | Down | -0.8666568725 |
| GSE24585 | Up | 0.7755721379 |
| GSE37065 | Up | 0.3847618194 |
| GSE28863_A1 | Up | 0.0290908012 |
| GSE28863_A2 | Down | -0.4609084871 |
| GSE28863_A3 | Up | 0.0305298166 |
| GSE28863_A4 | Down | -0.0803025051 |
| GSE48662 | Down | -0.0202253323 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One | DB01782 | EXPT00232 |
| Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine | DB02388 | EXPT00330 |
| Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine | DB03084 | EXPT00348 |
| 9-(4-Hydroxyphenyl)-2,7-Phenanthroline | DB03623 | EXPT00358 |
| Phosphoaminophosphonic Acid-Adenylate Ester | DB04395 | EXPT00524 |
| N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide | DB06933 | - |
| N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE | DB07010 | - |
| N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide | DB07217 | - |
| 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide | DB08005 | - |
| (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime | DB08010 | - |
| (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime | DB08011 | - |
| (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime | DB08015 | - |
| 5-bromo-N-(3-chloro-2-(4-(prop-2-ynyl)piperazin-1-yl)phenyl)furan-2-carboxamide | DB08021 | - |
| N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine | DB08023 | - |
| N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE | DB08025 | - |
| 2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide | DB08026 | - |
| 1-(3-bromophenyl)-7-chloro-6-methoxy-3,4-dihydroisoquinoline | DB08555 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 21 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26793112 | JNK's, particularly JNK3, not only enhance Abeta production, moreover it plays a key role in the maturation and development of neurofibrillary tangles |
| 26793112 | Keeping in mind that JNK3 is specifically expressed in the brain and activated by stress-stimuli, it is possible to hypothesize that inhibition of JNK3 might be considered as a potential target for treating neurodegenerative mechanisms associated with AD |
| 25697003 | Thus, NaBut-induced senescence upon suppressed activity of MEK/ERK-branch of MAP kinase cascade has a more pronounced tumor-suppressor effect associated with stronger activation of both mTOR-complexes, reorganization of the actin cytoskeleton and protein degradation |
| 25338966 | Instead, phosphorylation of p53 was mediated by Erk1/2 MAP kinase |
| 24950189 | Notch1 positively regulated the expression of inhibitor of DNA binding 1 (Id1) and MAP kinase phosphatase 1 (MKP1), while MKP1 further up-regulated Id1 expression by inhibiting p38MAPK-induced protein degradation |
| 22404905 | Importantly, the glucocorticoids suppressed the SASP without reverting the tumor suppressive growth arrest and were efficacious whether cells were induced to senesce by ionizing radiation or strong mitogenic signals delivered by oncogenic RAS or MAP kinase kinase 6 overexpression |
| 22010578 | Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling |
| 22008288 | Endosulfan may promote proliferation of T cells through MAP kinase (MAPK) activated signal transductions |
| 20362703 | Oncogenic activation of the RAS-ERK MAP kinase signaling pathway can lead to uncontrolled proliferation but can also result in apoptosis or premature cellular senescence, both regarded as natural protective barriers to cell immortalization and transformation |
| 20032303 | Changes in cellular expression of phosphoprotein enriched in astrocytes of 15 kDa (PEA-15) are linked to insulin resistance, tumor cell invasion, and cellular senescence; these changes alter the activation of the extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase pathway |
| 20032303 | This is the dominant mechanism by which PEA-15 activates ERK1/2 because genetic deletion of FRS2alpha blocked the capacity of PEA-15 to activate the MAP kinase pathway |
| 20032303 | Thus, PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway |
| 19355881 | Stress-activated MAP kinase cascades in cellular senescence |
| 18711403 | We identified universal genes regulating senescence/immortalization and found that the key regulator genes represented six pathways: the cell cycle pRB/p53, cytoskeletal, interferon-related, insulin growth factor-related, MAP kinase and oxidative stress pathway |
| 18391457 | Simultaneous addition of MAP kinase inhibitors, U0126, SB203580, and SP60025, effectively suppressed induction of premature senescence and senescence markers |
| 18259882 | For the in vivo phase, a differential expression of the ERK MAP kinase between tumor cells cultured in vitro and those inoculated in vivo was noted using Western blotting techniques |
| 17986575 | Recent studies suggest that the Ets transcription factor family, downstream of the mitogen signaling pathways of MAP kinase, regulates telomerase activity at the gene transcription level of human telomerase reverse transcriptase (hTERT) |
| 17077613 | We found that the MAP kinase cascade and histone acetylase have an important role in the signaling process to express p21 |
| 14567979 | Metabolic stabilization of MAP kinase phosphatase-2 in senescence of human fibroblasts |
| 14567979 | We have tested the hypothesis that this is due to elevated levels of nuclear MAP kinase phosphatase (MKP) activity in senescent cells |
| 11971980 | Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway |
| 11971980 | Taken together, our results indicate that oncogenic activation of the MAP kinase pathway in murine fibroblasts converts p53 into a senescence inducer through both quantitative and qualitative mechanisms |
| 10951233 | Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo |
| 10951233 | We report here that the extracellular-signal-regulated MAP kinase pathway is reduced and the stress-activated MAP kinase pathway is increased in old, compared with young, human skin in vivo |
| 10951233 | In contrast, stress-activated MAP kinase activity was elevated 3 |
| 10951233 | This increased activity resulted from enhanced activation, since total stress-activated MAP kinase protein levels were similar in old and young skin |
| 10951233 | Taken together, these data indicate that alterations in MAP kinase activities play a key role in the pathophysiology of human skin aging |
| 8733110 | Additionally, we examined the protein abundance of several members of the MAP kinase pathway which could play a role in c-fos induction by the PKC-dependent pathway |
| 8733110 | While we were unable to detect any decreases in PKC isoforms or MAP kinase proteins we cannot exclude the possibility that functional decrements accumulate in these proteins during senesence |
| 8162573 | This was accompanied by phosphorylation of the retinoblastoma and MAP-kinase proteins, as well as induction of the cdc2 protein |
| 8262140 | Both the 44- and 42-kDa forms of the MAP-kinase protein were expressed at similar levels in young and senescent cells |
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