HCSGD entry for MAPK9
1. General information
| Official gene symbol | MAPK9 |
|---|---|
| Entrez ID | 5601 |
| Gene full name | mitogen-activated protein kinase 9 |
| Other gene symbols | JNK-55 JNK2 JNK2A JNK2ALPHA JNK2B JNK2BETA PRKM9 SAPK SAPK1a p54a p54aSAPK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001836 | Release of cytochrome c from mitochondria | IEA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004705 | JUN kinase activity | IDA IEA | molecular_function |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006626 | Protein targeting to mitochondrion | IEA | biological_process |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0007254 | JNK cascade | IDA TAS | biological_process |
| GO:0007417 | Central nervous system development | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IDA IEA | molecular_function |
| GO:0008656 | Cysteine-type endopeptidase activator activity involved in apoptotic process | IEA | molecular_function |
| GO:0009612 | Response to mechanical stimulus | IEA | biological_process |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0010628 | Positive regulation of gene expression | IMP | biological_process |
| GO:0010744 | Positive regulation of macrophage derived foam cell differentiation | IMP | biological_process |
| GO:0010770 | Positive regulation of cell morphogenesis involved in differentiation | IEA | biological_process |
| GO:0014075 | Response to amine | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0031175 | Neuron projection development | IEA | biological_process |
| GO:0031394 | Positive regulation of prostaglandin biosynthetic process | IEA | biological_process |
| GO:0031396 | Regulation of protein ubiquitination | IEA | biological_process |
| GO:0031435 | Mitogen-activated protein kinase kinase kinase binding | IEA | molecular_function |
| GO:0032308 | Positive regulation of prostaglandin secretion | IEA | biological_process |
| GO:0032722 | Positive regulation of chemokine production | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0034644 | Cellular response to UV | IEA | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045429 | Positive regulation of nitric oxide biosynthetic process | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046328 | Regulation of JNK cascade | IEA | biological_process |
| GO:0046686 | Response to cadmium ion | IEA | biological_process |
| GO:0051090 | Regulation of sequence-specific DNA binding transcription factor activity | TAS | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0051770 | Positive regulation of nitric-oxide synthase biosynthetic process | IEA | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | IEA | biological_process |
| GO:0071347 | Cellular response to interleukin-1 | IEA | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IEA | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IEA | biological_process |
| GO:2001235 | Positive regulation of apoptotic signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9781511075 | 0.0409811633 | 0.9999902473 | 0.3814396960 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1241518108 |
| GSE13712_SHEAR | Down | -0.4424636165 |
| GSE13712_STATIC | Down | -0.0599439633 |
| GSE19018 | Down | -0.2520550443 |
| GSE19899_A1 | Down | -0.3413825168 |
| GSE19899_A2 | Down | -0.7384035585 |
| PubMed_21979375_A1 | Down | -0.7561880245 |
| PubMed_21979375_A2 | Down | -1.0582199804 |
| GSE35957 | Up | 0.0009811498 |
| GSE36640 | Up | 0.2788160270 |
| GSE54402 | Down | -0.1983664922 |
| GSE9593 | Up | 0.1951090060 |
| GSE43922 | Down | -0.0831639475 |
| GSE24585 | Down | -0.1140040575 |
| GSE37065 | Up | 0.1308288295 |
| GSE28863_A1 | Down | -0.0329401485 |
| GSE28863_A2 | Up | 0.0641751205 |
| GSE28863_A3 | Down | -0.3954155552 |
| GSE28863_A4 | Down | -0.3093845894 |
| GSE48662 | Down | -0.1339804605 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide | DB07020 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT003240 | Luciferase reporter assay | Non-Functional MTI | 20065103 |
| hsa-miR-199a-3p | MIMAT0000232 | MIRT003982 | Western blot | Non-Functional MTI | 18456660 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT004359 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 18700987 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT004359 | Luciferase reporter assay | Non-Functional MTI | 21283765 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT005856 | Luciferase reporter assay | Non-Functional MTI | 21283765 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005864 | Luciferase reporter assay | Non-Functional MTI | 21283765 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT021647 | Western blot | Functional MTI | 20053927 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024284 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025800 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026550 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-27b-3p | MIMAT0000419 | MIRT046207 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049753 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27812125 | Genes-toll-interacting protein (TOLLIP), mitogen-activated protein kinase 9 (MAPK9), interleukin-1beta (IL-1beta), interleukin-8 (IL-8), and chemokine (C-X-C motif) ligand 1 (CXCL1)-related to these two pathways were validated using western blotting |
| 22569127 | Genetic inactivation of the SAPK or the CDKi abolishes cell-cycle delay upon osmostress and results in decreased cell viability |
| 20354187 | Here, we report that JNK2 is activated in more than 70% of human squamous cell carcinoma (SCC) samples and that inhibition of JNK2 pharmacologically or genetically impairs tumorigenesis of human SCC cells |
| 20354187 | Most importantly, JNK2, but not JNK1, is sufficient to couple with oncogenic Ras to transform primary human epidermal cells into malignancy with features of SCC |
| 20354187 | JNK2 prevents Ras-induced cell senescence and growth arrest by reducing the expression levels of the cell cycle inhibitor p16 and the activation of NF-kappaB |
| 20354187 | These data indicate that JNK2 collaborates with other oncogenes, such as Ras, at multiple molecular levels to promote tumorigenesis and hence represents a promising therapeutic target for cancer |
| 18952756 | Western blotting of freshly isolated AEC2 lysates for stress signaling kinases confirmed that the stress-activated protein kinase (SAPK)/c-Jun NH(2)-terminal kinase (JNK) stress response pathway is stimulated in telomerase-null AEC2 even under normoxic conditions |
| 12470828 | The accumulation of ROS in senescent cells may be related to the constitutive activation of Jun kinase |
| 11480555 | While ceramide stimulates signal transduction pathways that are associated with cell death or at least are inhibitory to cell growth (eg stress-activated protein kinase, SAPK, pathways), DAG activates the classical and novel isoforms of the protein kinase C (PKC) family |
| 10987139 | The SAPK/JNK activation by UV irradiation was reduced in both non-treated senescent cells and the hydrogen peroxide-induced senescent cells, suggesting that a reduced DNA fragmentation by UV-irradiation in the senescent cells is closely related to the decreased SAPK/JNK activity |
| 10987139 | Since a cell cycle inhibitor, p21Waf1, has been implicated in protecting cells against apoptotic cell death, we determined p21Waf1 to assess whether its elevation has any impact on the reduction of UV-induced activation of SAPK/JNK in the senescent cells |
| 10987139 | Our study also revealed that the blockage of SAPK/JNK activation in the senescent cells was closely related to the increased level of p21Waf1 |
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