HCSGD entry for MAPK11

1. General information

Official gene symbolMAPK11
Entrez ID5600
Gene full namemitogen-activated protein kinase 11
Other gene symbolsP38B P38BETA2 PRKM11 SAPK2 SAPK2B p38-2 p38Beta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityTASmolecular_function
GO:0004707MAP kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006950Response to stressIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13304772240.91165295770.73834052291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0640877536
GSE13712_SHEARDown-0.0208261501
GSE13712_STATICUp0.1045425822
GSE19018Up0.0828203857
GSE19899_A1Up0.0202067104
GSE19899_A2Up0.7556345654
PubMed_21979375_A1Up0.6753951278
PubMed_21979375_A2Up0.0105006954
GSE35957Up0.1824716689
GSE36640Up0.3814548749
GSE54402Up0.0719039554
GSE9593Up0.2562891823
GSE43922Up0.1487507615
GSE24585Up0.1300032184
GSE37065Down-0.1980816541
GSE28863_A1Down-0.4386116248
GSE28863_A2Down-0.2445831836
GSE28863_A3Up0.3336315622
GSE28863_A4Up0.0446347741
GSE48662Up0.4229914520

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

KC706DB05157 -
RegorafenibDB08896 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-122-5pMIMAT0000421MIRT003097Luciferase reporter assay//qRT-PCRFunctional MTI19296470
hsa-miR-124-3pMIMAT0000422MIRT022536MicroarrayFunctional MTI (Weak)18668037
hsa-let-7a-5pMIMAT0000062MIRT052537CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.