HCSGD entry for MAPK6
1. General information
| Official gene symbol | MAPK6 |
|---|---|
| Entrez ID | 5597 |
| Gene full name | mitogen-activated protein kinase 6 |
| Other gene symbols | ERK3 HsT17250 PRKM6 p97MAPK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0004707 | MAP kinase activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0786630371 | 0.7320234148 | 0.5909999715 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3012360573 |
| GSE13712_SHEAR | Down | -0.0111701015 |
| GSE13712_STATIC | Up | 0.0835355605 |
| GSE19018 | Down | -0.0047045114 |
| GSE19899_A1 | Up | 0.6727327021 |
| GSE19899_A2 | Up | 0.1294684022 |
| PubMed_21979375_A1 | Up | 0.7948098145 |
| PubMed_21979375_A2 | Up | 0.5440084162 |
| GSE35957 | Up | 0.2664893748 |
| GSE36640 | Down | -0.2089239747 |
| GSE54402 | Up | 0.1474670918 |
| GSE9593 | Down | -0.1153701373 |
| GSE43922 | Up | 0.6139469482 |
| GSE24585 | Down | -0.1145005468 |
| GSE37065 | Up | 0.3131674510 |
| GSE28863_A1 | Down | -0.0488667547 |
| GSE28863_A2 | Down | -0.3025924432 |
| GSE28863_A3 | Down | -0.1731160445 |
| GSE28863_A4 | Up | 0.1175974661 |
| GSE48662 | Down | -0.7864923320 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT021894 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048392 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048608 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT051334 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
