HCSGD entry for MAPK1

1. General information

Official gene symbolMAPK1
Entrez ID5594
Gene full namemitogen-activated protein kinase 1
Other gene symbolsERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeTASbiological_process
GO:0000186Activation of MAPKK activityTASbiological_process
GO:0000187Activation of MAPK activityTASbiological_process
GO:0000189MAPK import into nucleusIEAbiological_process
GO:0001784Phosphotyrosine bindingIEAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0005739MitochondrionTAScellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005770Late endosomeTAScellular_component
GO:0005794Golgi apparatusTAScellular_component
GO:0005815Microtubule organizing centerIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005901CaveolaTAScellular_component
GO:0005925Focal adhesionTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006950Response to stressTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIEAbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityISSmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009887Organ morphogenesisIEAbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationIDAbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationISSbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0019858Cytosine metabolic processIEAbiological_process
GO:0019902Phosphatase bindingIPImolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0031143PseudopodiumIEAcellular_component
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0031647Regulation of protein stabilityISSbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032839Dendrite cytoplasmIEAcellular_component
GO:0032872Regulation of stress-activated MAPK cascadeTASbiological_process
GO:0033598Mammary gland epithelial cell proliferationIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0038127ERBB signaling pathwayIDAbiological_process
GO:0043204PerikaryonIEAcellular_component
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045596Negative regulation of cell differentiationIEAbiological_process
GO:0045727Positive regulation of translationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0051493Regulation of cytoskeleton organizationTASbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTASbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEAbiological_process
GO:0070371ERK1 and ERK2 cascadeIDA TASbiological_process
GO:0070849Response to epidermal growth factorIDAbiological_process
GO:0072584Caveolin-mediated endocytosisTASbiological_process
GO:0072686Mitotic spindleISScellular_component
GO:0090170Regulation of Golgi inheritanceTASbiological_process
GO:2000641Regulation of early endosome to late endosome transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24270068010.90920283040.92992211231.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1137087216
GSE13712_SHEARUp0.0119932894
GSE13712_STATICDown-0.1050192902
GSE19018Up0.1545333962
GSE19899_A1Down-0.1366792953
GSE19899_A2Up0.4285501309
PubMed_21979375_A1Up0.3341175064
PubMed_21979375_A2Down-0.3118504125
GSE35957Up0.0915468722
GSE36640Up0.0836692403
GSE54402Up0.1563749788
GSE9593Up0.3240100844
GSE43922Up0.0352844156
GSE24585Up0.4135195961
GSE37065Up0.1455072105
GSE28863_A1Up0.0336689291
GSE28863_A2Up0.2358903938
GSE28863_A3Down-0.4128447352
GSE28863_A4Up0.1655983823
GSE48662Down-0.3210753536

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL207544CHEMBL40409P28482
CHEMBL255465CHEMBL40409P28482
CHEMBL35482CHEMBL40409P28482
CHEMBL162CHEMBL40409P28482
CHEMBL151430CHEMBL40409P28482
CHEMBL359106CHEMBL40409P28482
CHEMBL210390CHEMBL40409P28482
CHEMBL383541CHEMBL40409P28482
CHEMBL383264CHEMBL40409P28482
CHEMBL210618CHEMBL40409P28482
CHEMBL162CHEMBL40409P28482
CHEMBL210963CHEMBL40409P28482
CHEMBL162CHEMBL40409P28482
CHEMBL509032CHEMBL40409P28482
CHEMBL162CHEMBL40409P28482
CHEMBL383264CHEMBL40409P28482
CHEMBL378627CHEMBL40409P28482
CHEMBL162CHEMBL40409P28482
CHEMBL332551CHEMBL40409P28482
CHEMBL378963CHEMBL40409P28482
CHEMBL440356CHEMBL40409P28482
CHEMBL383541CHEMBL40409P28482
CHEMBL361708CHEMBL40409P28482
CHEMBL606964CHEMBL40409P28482
CHEMBL361708CHEMBL40409P28482
CHEMBL255465CHEMBL40409P28482
CHEMBL379218CHEMBL40409P28482
CHEMBL259551CHEMBL40409P28482
CHEMBL380946CHEMBL40409P28482
CHEMBL18797CHEMBL40409P28482
CHEMBL226471CHEMBL40409P28482
CHEMBL220110CHEMBL40409P28482
CHEMBL220320CHEMBL40409P28482
CHEMBL421CHEMBL40409P28482
CHEMBL408CHEMBL40409P28482
CHEMBL220882CHEMBL40409P28482
CHEMBL220888CHEMBL40409P28482
CHEMBL220343CHEMBL40409P28482
CHEMBL395080CHEMBL40409P28482
CHEMBL222841CHEMBL40409P28482
CHEMBL383104CHEMBL40409P28482
CHEMBL220054CHEMBL40409P28482
CHEMBL373797CHEMBL40409P28482
CHEMBL220174CHEMBL40409P28482
CHEMBL509CHEMBL40409P28482
CHEMBL1909070CHEMBL40409P28482
CHEMBL220272CHEMBL40409P28482
CHEMBL370379CHEMBL40409P28482
CHEMBL373628CHEMBL40409P28482
CHEMBL12131CHEMBL40409P28482
CHEMBL223471CHEMBL40409P28482
CHEMBL86754CHEMBL40409P28482
CHEMBL219849CHEMBL40409P28482
CHEMBL220112CHEMBL40409P28482
CHEMBL221096CHEMBL40409P28482
CHEMBL220897CHEMBL40409P28482
CHEMBL221271CHEMBL40409P28482
CHEMBL38CHEMBL40409P28482
CHEMBL603CHEMBL40409P28482
CHEMBL373598CHEMBL40409P28482
CHEMBL375544CHEMBL40409P28482
CHEMBL388590CHEMBL40409P28482
CHEMBL222465CHEMBL40409P28482
CHEMBL291338CHEMBL40409P28482
CHEMBL496CHEMBL40409P28482
CHEMBL219790CHEMBL40409P28482
CHEMBL219988CHEMBL40409P28482
CHEMBL369976CHEMBL40409P28482
CHEMBL377383CHEMBL40409P28482
CHEMBL374876CHEMBL40409P28482
CHEMBL242237CHEMBL40409P28482
CHEMBL211501CHEMBL40409P28482
CHEMBL220574CHEMBL40409P28482
CHEMBL24944CHEMBL40409P28482
CHEMBL221109CHEMBL40409P28482
CHEMBL319244CHEMBL40409P28482
CHEMBL547CHEMBL40409P28482
CHEMBL199395CHEMBL40409P28482
CHEMBL387385CHEMBL40409P28482
CHEMBL1406CHEMBL40409P28482
CHEMBL219683CHEMBL40409P28482
CHEMBL1668411CHEMBL40409P28482
CHEMBL222249CHEMBL40409P28482
CHEMBL374677CHEMBL40409P28482
CHEMBL220096CHEMBL40409P28482
CHEMBL375525CHEMBL40409P28482
CHEMBL221117CHEMBL40409P28482
CHEMBL375621CHEMBL40409P28482
CHEMBL220169CHEMBL40409P28482
CHEMBL226403CHEMBL40409P28482
CHEMBL1466CHEMBL40409P28482
CHEMBL219841CHEMBL40409P28482
CHEMBL93645CHEMBL40409P28482
CHEMBL290106CHEMBL40409P28482
CHEMBL373448CHEMBL40409P28482
CHEMBL570111CHEMBL40408P28482
CHEMBL572361CHEMBL40408P28482
CHEMBL143054CHEMBL40408P28482
CHEMBL99203CHEMBL40408P28482
CHEMBL259551CHEMBL40408P28482
CHEMBL1092754CHEMBL40408P28482
CHEMBL247619CHEMBL40408P28482
CHEMBL262615CHEMBL40408P28482
CHEMBL570367CHEMBL40408P28482
CHEMBL499237CHEMBL40408P28482
CHEMBL576048CHEMBL40408P28482
CHEMBL247798CHEMBL40408P28482
CHEMBL571722CHEMBL40408P28482
CHEMBL1684800CHEMBL40408P28482
CHEMBL247250CHEMBL40408P28482
CHEMBL1651521CHEMBL40408P28482
CHEMBL296586CHEMBL40408P28482
CHEMBL570366CHEMBL40408P28482
CHEMBL14762CHEMBL40408P28482
CHEMBL568483CHEMBL40408P28482
CHEMBL259551CHEMBL40408P28482
CHEMBL582829CHEMBL40408P28482
CHEMBL1952210CHEMBL40408P28482
CHEMBL569181CHEMBL40408P28482
CHEMBL247797CHEMBL40408P28482
CHEMBL571030CHEMBL40408P28482
CHEMBL162CHEMBL40408P28482
CHEMBL1234833CHEMBL40408P28482
CHEMBL507666CHEMBL40408P28482
CHEMBL190710CHEMBL40408P28482
CHEMBL75680CHEMBL40408P28482
CHEMBL519113CHEMBL40408P28482
CHEMBL454617CHEMBL40408P28482
CHEMBL397332CHEMBL40408P28482
CHEMBL1082152CHEMBL40408P28482
CHEMBL1922215CHEMBL40408P28482
CHEMBL445178CHEMBL40408P28482
CHEMBL1922217CHEMBL40408P28482
CHEMBL486540CHEMBL40408P28482
CHEMBL524266CHEMBL40408P28482
CHEMBL1922212CHEMBL40408P28482
CHEMBL1682021CHEMBL40408P28482
CHEMBL520882CHEMBL40408P28482
CHEMBL162CHEMBL40408P28482
CHEMBL14762CHEMBL40408P28482
CHEMBL1922120CHEMBL40408P28482
CHEMBL1922199CHEMBL40408P28482
CHEMBL363555CHEMBL40408P28482
CHEMBL1922123CHEMBL40408P28482
CHEMBL1922208CHEMBL40408P28482
CHEMBL1922122CHEMBL40408P28482
CHEMBL1922114CHEMBL40408P28482
CHEMBL103667CHEMBL40408P28482
CHEMBL246088CHEMBL40408P28482
CHEMBL1922210CHEMBL40408P28482
CHEMBL466496CHEMBL40408P28482
CHEMBL467079CHEMBL40408P28482
CHEMBL280074CHEMBL40408P28482
CHEMBL1922213CHEMBL40408P28482
CHEMBL455641CHEMBL40408P28482
CHEMBL1242973CHEMBL40408P28482
CHEMBL599224CHEMBL40408P28482
CHEMBL437943CHEMBL40408P28482
CHEMBL1922205CHEMBL40408P28482
CHEMBL162CHEMBL40408P28482
CHEMBL274064CHEMBL40408P28482
CHEMBL487153CHEMBL40408P28482
CHEMBL1644619CHEMBL40408P28482
CHEMBL1922209CHEMBL40408P28482
CHEMBL511410CHEMBL40408P28482
CHEMBL1922214CHEMBL40408P28482
CHEMBL461140CHEMBL40408P28482
CHEMBL1922119CHEMBL40408P28482
CHEMBL486541CHEMBL40408P28482
CHEMBL461139CHEMBL40408P28482
CHEMBL245884CHEMBL40408P28482
CHEMBL557003CHEMBL40408P28482
CHEMBL487356CHEMBL40408P28482
CHEMBL77155CHEMBL40408P28482
CHEMBL1288128CHEMBL40408P28482
CHEMBL520871CHEMBL40408P28482
CHEMBL280074CHEMBL40408P28482
CHEMBL549385CHEMBL40408P28482
CHEMBL487154CHEMBL40408P28482
CHEMBL455389CHEMBL40408P28482
CHEMBL428690CHEMBL40408P28482
CHEMBL246089CHEMBL40408P28482
CHEMBL1644626CHEMBL40408P28482
CHEMBL597754CHEMBL40408P28482
CHEMBL364953CHEMBL40408P28482
CHEMBL1922211CHEMBL40408P28482
CHEMBL1922204CHEMBL40408P28482
CHEMBL599428CHEMBL40408P28482
CHEMBL393929CHEMBL40405P28482
CHEMBL235345CHEMBL40405P28482
CHEMBL57347CHEMBL40404P28482
CHEMBL45827CHEMBL40404P28482
CHEMBL56983CHEMBL40404P28482
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  • Drugs

Name

Drug

Accession number

OlomoucineDB02116 EXPT02433
PhosphonothreonineDB02482 EXPT03092
PurvalanolDB02733 EXPT02705
SB220025DB04338 EXPT02849
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDEDB06877 -
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDEDB07010 -
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDEDB07264 -
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONEDB07788 -
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINEDB07794 -
(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dioneDB07905 -
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDB08513 -
4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINEDB08521 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT006447Immunofluorescence//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22382496
hsa-miR-28-5pMIMAT0000085MIRT006418Luciferase reporter assayFunctional MTI20445018
hsa-miR-199a-3pMIMAT0000232MIRT003983Luciferase reporter assayFunctional MTI18456660
hsa-miR-320aMIMAT0000510MIRT007093Luciferase reporter assayFunctional MTI23196978
hsa-miR-30a-5pMIMAT0000087MIRT028452ProteomicsFunctional MTI (Weak)18668040
hsa-miR-766-3pMIMAT0003888MIRT039037CLASHFunctional MTI (Weak)23622248
hsa-miR-769-5pMIMAT0003886MIRT039161CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040549CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046445CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052280CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24408923The extracellular signal-regulated kinase ERK1 and ERK2 (ERK1/2) cascade regulates a variety of cellular processes by phosphorylating multiple target proteins
23599344Surprisingly, attenuation of ERK/MAP kinase signaling by genetic inactivation of Erk2, RNAi-mediated knockdown of ERK1 or ERK2, or MEK inhibitors prevented the activation of the senescence mechanism, allowing oncogenic ras to transform primary cells
22521293Using specific antibodies, a complex formation between ETS1 and extracellular signal-regulated kinase-2 (ERK2) was shown
22521293SIGNIFICANCE: ETS1, ERK2 and Mxi2 are important complex partners initiating increased p16(INK4a) and p21w(af1/cip1) activation in renal tumor cells
22008288The ERK family of MAPKs includes ERK1 and ERK2
21628992In this study, we demonstrate that p41-Arc can induce senescent phenotypes when it is overexpressed in human tumor cell line, SaOs-2, which is deficient in p53 and Rb tumor suppressor genes, implying that p41 can induce senescence in a p53-independent way
17276372Approximately 90% of the cells expressed HHV-6B p41, indicative of viral infection
17145763Nuclear targeting of ERK2(D319N) significantly augments its effects and the transduced cultures show higher than 60% increase in replicative lifespan compared with cultures transduced with wt ERK2
17145763Our results support that MKP2-mediated inactivation of nuclear ERK2 represents a key event in the establishment of replicative senescence
12646231An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2
10748101By elaborately localizing ERK2 in the nuclei of senescent cells, we could restore c-fos transcriptional activity upon growth stimuli, which was repressed in senescent cells
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