HCSGD entry for RNF114
1. General information
| Official gene symbol | RNF114 |
|---|---|
| Entrez ID | 55905 |
| Gene full name | ring finger protein 114 |
| Other gene symbols | PSORS12 ZNF313 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0030154 | Cell differentiation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0321798982 | 0.9393463660 | 0.4142465071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7976947600 |
| GSE13712_SHEAR | Up | 0.2951480716 |
| GSE13712_STATIC | Up | 0.5754578447 |
| GSE19018 | Down | -0.2647388169 |
| GSE19899_A1 | Up | 0.2972977008 |
| GSE19899_A2 | Down | -0.0499572629 |
| PubMed_21979375_A1 | Up | 0.3972024554 |
| PubMed_21979375_A2 | Down | -0.0355377622 |
| GSE35957 | Down | -0.3840749339 |
| GSE36640 | Down | -0.0125567048 |
| GSE54402 | Up | 0.2084570772 |
| GSE9593 | Up | 0.2950242388 |
| GSE43922 | Up | 0.0059664017 |
| GSE24585 | Up | 0.0996578230 |
| GSE37065 | Up | 0.5708884922 |
| GSE28863_A1 | Up | 0.7242557715 |
| GSE28863_A2 | Up | 0.6416156790 |
| GSE28863_A3 | Up | 0.0325174196 |
| GSE28863_A4 | Up | 0.0567348268 |
| GSE48662 | Down | -0.3145806759 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025727 | Microarray | Functional MTI (Weak) | 19073608 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23645206 | ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1 |
| 23645206 | ZNF313 encoding a zinc-binding protein is located at chromosome 20q13 |
| 23645206 | However, the biological function of ZNF313 remains largely undefined |
| 23645206 | Here we report that ZNF313 is an ubiquitin E3 ligase that has a critical role in the regulation of cell cycle progression, differentiation and senescence |
| 23645206 | In this study, ZNF313 is initially identified as a XIAP-associated factor 1 (XAF1)-interacting protein, which upregulates the stability and proapoptotic effect of XAF1 |
| 23645206 | ZNF313 ubiquitinates p21(WAF1) and also destabilizes p27(KIP1) and p57(KIP2), three members of the CDK-interacting protein (CIP)/kinase inhibitor protein (KIP) family of cyclin-dependent kinase inhibitors, whereas it does not affect the stability of the inhibitor of CDK (INK4) family members, such as p16(INK4A) and p15(INK4B) |
| 23645206 | ZNF313 expression is tightly controlled during the cell cycle and its elevation at the late G1 phase is crucial for the G1-to-S phase transition |
| 23645206 | ZNF313 is induced by mitogenic growth factors and its blockade profoundly delays cell cycle progression and accelerates p21(WAF1)-mediated senescence |
| 23645206 | Both replicative and stress-induced senescence are accompanied with ZNF313 reduction |
| 23645206 | ZNF313 shows both the nuclear and cytoplasmic localization in epithelial cells of normal tissues, but exhibits an intense cytoplasmic distribution in carcinoma cells of tumor tissues |
| 23645206 | Collectively, ZNF313 is a novel E3 ligase for p21(WAF1), whose alteration might be implicated in the pathogenesis of several human diseases, including cancers |
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