HCSGD entry for PRKCZ

1. General information

Official gene symbolPRKCZ
Entrez ID5590
Gene full nameprotein kinase C, zeta
Other gene symbolsPKC-ZETA PKC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0001954Positive regulation of cell-matrix adhesionIEAbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004697Protein kinase C activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005635Nuclear envelopeIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005923Tight junctionIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007616Long-term memoryIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008286Insulin receptor signaling pathwayIEAbiological_process
GO:0015459Potassium channel regulator activityIEAmolecular_function
GO:0016020MembraneTAScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0016363Nuclear matrixIEAcellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIDA IEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030010Establishment of cell polarityIEA ISSbiological_process
GO:0030054Cell junctionTAScellular_component
GO:0030168Platelet activationTASbiological_process
GO:0031252Cell leading edgeIEAcellular_component
GO:0031333Negative regulation of protein complex assemblyIMPbiological_process
GO:0031532Actin cytoskeleton reorganizationIEAbiological_process
GO:0031584Activation of phospholipase D activityIEAbiological_process
GO:0032148Activation of protein kinase B activityIEAbiological_process
GO:0032753Positive regulation of interleukin-4 productionIEA ISSbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0035748Myelin sheath abaxonal regionIEAcellular_component
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043274Phospholipase bindingIEAmolecular_function
GO:0043560Insulin receptor substrate bindingICmolecular_function
GO:0045121Membrane raftIEAcellular_component
GO:0045179Apical cortexIEAcellular_component
GO:0045630Positive regulation of T-helper 2 cell differentiationIEA ISSbiological_process
GO:0046326Positive regulation of glucose importIEAbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIMPbiological_process
GO:0046628Positive regulation of insulin receptor signaling pathwayIEA ISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0047496Vesicle transport along microtubuleIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIMPbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEA ISSbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051346Negative regulation of hydrolase activityIEAbiological_process
GO:0060081Membrane hyperpolarizationIEAbiological_process
GO:0060291Long-term synaptic potentiationIEA ISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070528Protein kinase C signalingIEAbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
GO:0072659Protein localization to plasma membraneIEAbiological_process
GO:2000463Positive regulation of excitatory postsynaptic membrane potentialIEA ISSbiological_process
GO:2000553Positive regulation of T-helper 2 cell cytokine productionIEA ISSbiological_process
GO:2000664Positive regulation of interleukin-5 secretionIEA ISSbiological_process
GO:2000667Positive regulation of interleukin-13 secretionIEA ISSbiological_process
GO:2001181Positive regulation of interleukin-10 secretionIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.14485091370.55036337150.76298196921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4745731969
GSE13712_SHEARDown-0.9846577706
GSE13712_STATICDown-0.0334744088
GSE19018Down-0.1535193994
GSE19899_A1Down-0.0902793139
GSE19899_A2Up0.2740963110
PubMed_21979375_A1Up0.9195331922
PubMed_21979375_A2Down-0.0883392322
GSE35957Down-0.1929665265
GSE36640Down-0.1343642733
GSE54402Down-0.0679296806
GSE9593Up0.5280260360
GSE43922Up0.0391664209
GSE24585Up0.4693548284
GSE37065Up0.0112910465
GSE28863_A1Down-0.2043897872
GSE28863_A2Down-0.0160725297
GSE28863_A3Up0.2617175042
GSE28863_A4Up0.1362719595
GSE48662Down-0.0313778066

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.