HCSGD entry for PRKCQ

1. General information

Official gene symbol	PRKCQ
Entrez ID	5588
Gene full name	protein kinase C, theta
Other gene symbols	PRKCT nPKC-theta
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001558	Regulation of cell growth	NAS	biological_process
GO:0001772	Immunological synapse	IEA	cellular_component
GO:0004674	Protein serine/threonine kinase activity	IEA NAS TAS	molecular_function
GO:0004697	Protein kinase C activity	IEA	molecular_function
GO:0004842	Ubiquitin-protein ligase activity	TAS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005829	Cytosol	TAS	cellular_component
GO:0005886	Plasma membrane	TAS	cellular_component
GO:0006355	Regulation of transcription, DNA-templated	ISS	biological_process
GO:0006509	Membrane protein ectodomain proteolysis	ISS	biological_process
GO:0006915	Apoptotic process	TAS	biological_process
GO:0006921	Cellular component disassembly involved in execution phase of apoptosis	TAS	biological_process
GO:0006954	Inflammatory response	IEA	biological_process
GO:0007411	Axon guidance	TAS	biological_process
GO:0007596	Blood coagulation	TAS	biological_process
GO:0007603	Phototransduction, visible light	TAS	biological_process
GO:0016056	Rhodopsin mediated signaling pathway	TAS	biological_process
GO:0016567	Protein ubiquitination	TAS	biological_process
GO:0022400	Regulation of rhodopsin mediated signaling pathway	TAS	biological_process
GO:0030168	Platelet activation	TAS	biological_process
GO:0032740	Positive regulation of interleukin-17 production	ISS	biological_process
GO:0032753	Positive regulation of interleukin-4 production	ISS	biological_process
GO:0035556	Intracellular signal transduction	IEA NAS	biological_process
GO:0038095	Fc-epsilon receptor signaling pathway	TAS	biological_process
GO:0042102	Positive regulation of T cell proliferation	IEA	biological_process
GO:0045086	Positive regulation of interleukin-2 biosynthetic process	IEA	biological_process
GO:0045087	Innate immune response	TAS	biological_process
GO:0046627	Negative regulation of insulin receptor signaling pathway	IMP	biological_process
GO:0046872	Metal ion binding	IEA	molecular_function
GO:0050852	T cell receptor signaling pathway	TAS	biological_process
GO:0050870	Positive regulation of T cell activation	ISS	biological_process
GO:0051092	Positive regulation of NF-kappaB transcription factor activity	IDA	biological_process
GO:0070233	Negative regulation of T cell apoptotic process	IMP	biological_process
GO:0090330	Regulation of platelet aggregation	ISS	biological_process
GO:2000318	Positive regulation of T-helper 17 type immune response	ISS	biological_process
GO:2000570	Positive regulation of T-helper 2 cell activation	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.8866915353	0.4605199461	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.1147845513
GSE13712_SHEAR	Down	-0.7330918648
GSE13712_STATIC	Down	-0.6192456556
GSE19018	Up	0.0551721098
GSE19899_A1	Up	0.1151550525
GSE19899_A2	Up	0.0921259496
PubMed_21979375_A1	Down	-0.0478149405
PubMed_21979375_A2	Down	-0.1077745390
GSE35957	Up	0.2368213584
GSE36640	Up	0.0511336837
GSE54402	Up	0.0073279014
GSE9593	Up	0.0607201310
GSE43922	Up	0.0181195573
GSE24585	Up	0.0080754135
GSE37065	Down	-0.0484476869
GSE28863_A1	Up	0.0393048825
GSE28863_A2	Down	-0.0922813904
GSE28863_A3	Up	0.1752758773
GSE28863_A4	Up	0.0556530132
GSE48662	Down	-0.0069156264

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Staurosporine	DB02010	EXPT02970 \| EXPT02972
Phosphonothreonine	DB02482	EXPT03092
Phosphonoserine	DB04522	EXPT02883

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for PRKCQ

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )