HCSGD entry for PRKD1

1. General information

Official gene symbolPRKD1
Entrez ID5587
Gene full nameprotein kinase D1
Other gene symbolsPKC-MU PKCM PKD PRKCM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001938Positive regulation of endothelial cell proliferationIGIbiological_process
GO:0004674Protein serine/threonine kinase activityIDA TASmolecular_function
GO:0004697Protein kinase C activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005802Trans-Golgi networkIDAcellular_component
GO:0005829CytosolISS TAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007030Golgi organizationIMPbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007229Integrin-mediated signaling pathwayTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0010837Regulation of keratinocyte proliferationISSbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0030148Sphingolipid biosynthetic processTASbiological_process
GO:0032793Positive regulation of CREB transcription factor activityIGIbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIGIbiological_process
GO:0034599Cellular response to oxidative stressIDAbiological_process
GO:0035556Intracellular signal transductionIEA IGI IMPbiological_process
GO:0035924Cellular response to vascular endothelial growth factor stimulusIGI IMPbiological_process
GO:0038033Positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathwayIGI IMPbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043536Positive regulation of blood vessel endothelial cell migrationIGI IMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationISSbiological_process
GO:0045766Positive regulation of angiogenesisIGI IMPbiological_process
GO:0045806Negative regulation of endocytosisTASbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0046777Protein autophosphorylationTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIMPbiological_process
GO:0048193Golgi vesicle transportISSbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0060548Negative regulation of cell deathIMPbiological_process
GO:1901727Positive regulation of histone deacetylase activityIGIbiological_process
GO:2001028Positive regulation of endothelial cell chemotaxisIMPbiological_process
GO:2001044Regulation of integrin-mediated signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98684330760.00042088070.99999024730.0382505155

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.2703401698
GSE13712_SHEARDown-0.6552338459
GSE13712_STATICDown-0.4733414247
GSE19018Up0.1038485185
GSE19899_A1Down-1.1576152339
GSE19899_A2Down-0.9733504641
PubMed_21979375_A1Down-2.3561888151
PubMed_21979375_A2Down-1.9048132422
GSE35957Up0.6642120047
GSE36640Up0.1089623428
GSE54402Down-1.3301013885
GSE9593Down-0.2454568590
GSE43922Down-1.8035514026
GSE24585Up0.1489375553
GSE37065Down-0.4012369918
GSE28863_A1Up0.0332493937
GSE28863_A2Down-0.5916966527
GSE28863_A3Down-0.7031378032
GSE28863_A4Down-0.0160467694
GSE48662Down-0.4554703010

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT052152CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24828530Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
24828530Here, we identify protein kinase D1 (PKD1) as a downstream effector of ROS signaling to mediate Ras OIS and SASP
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