HCSGD entry for PKN1

1. General information

Official gene symbolPKN1
Entrez ID5585
Gene full nameprotein kinase N1
Other gene symbolsDBK PAK-1 PAK1 PKN PKN-ALPHA PRK1 PRKCL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003682Chromatin bindingIDAmolecular_function
GO:0004672Protein kinase activityTASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004697Protein kinase C activityIEAmolecular_function
GO:0005080Protein kinase C bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006972Hyperosmotic responseIEAbiological_process
GO:0007165Signal transductionIEA TASbiological_process
GO:0007257Activation of JUN kinase activityTASbiological_process
GO:0010631Epithelial cell migrationIMPbiological_process
GO:0016023Cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0017049GTP-Rho bindingIDAmolecular_function
GO:0030374Ligand-dependent nuclear receptor transcription coactivator activityIDA IMPmolecular_function
GO:0030496MidbodyIDAcellular_component
GO:0032154Cleavage furrowIDAcellular_component
GO:0035402Histone kinase activity (H3-T11 specific)IDAmolecular_function
GO:0035407Histone H3-T11 phosphorylationIDAbiological_process
GO:0042393Histone bindingIDAmolecular_function
GO:0042826Histone deacetylase bindingIDAmolecular_function
GO:0048365Rac GTPase bindingIDAmolecular_function
GO:0050681Androgen receptor bindingIDAmolecular_function
GO:2000145Regulation of cell motilityIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24135880860.14017683600.92850119850.7204447502

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0396484264
GSE13712_SHEARDown-0.3092683442
GSE13712_STATICDown-0.2834028080
GSE19018Up0.3926967781
GSE19899_A1Up0.0221404393
GSE19899_A2Up0.2531139038
PubMed_21979375_A1Up0.2549063420
PubMed_21979375_A2Up0.9052528432
GSE35957Down-0.7796307348
GSE36640Down-0.0893737910
GSE54402Down-0.3559266158
GSE9593Up0.4135231628
GSE43922Up0.0469524333
GSE24585Down-0.4949644020
GSE37065Down-0.2451325130
GSE28863_A1Down-0.0140487719
GSE28863_A2Up0.0128038937
GSE28863_A3Down-0.5717168567
GSE28863_A4Up0.1078716636
GSE48662Up0.4005817514

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029573MicroarrayFunctional MTI (Weak)19088304
hsa-miR-425-3pMIMAT0001343MIRT042418CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049164CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-7-5pMIMAT0000252NAhsa-miR-7{Western blot}{overexpression by miRNA mimics tranfection}18922890
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.