HCSGD entry for PRKCI

1. General information

Official gene symbolPRKCI
Entrez ID5584
Gene full nameprotein kinase C, iota
Other gene symbolsDXS1179E PKCI nPKC-iota
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000133PolarisomeTAScellular_component
GO:0000139Golgi membraneIEAcellular_component
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA TASmolecular_function
GO:0004697Protein kinase C activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingTASmolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006612Protein targeting to membraneNASbiological_process
GO:0007010Cytoskeleton organizationNASbiological_process
GO:0007015Actin filament organizationIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0016192Vesicle-mediated transportTASbiological_process
GO:0016324Apical plasma membraneIEAcellular_component
GO:0016477Cell migrationIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0031252Cell leading edgeIEAcellular_component
GO:0032869Cellular response to insulin stimulusISSbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0034351Negative regulation of glial cell apoptotic processIMPbiological_process
GO:0035089Establishment of apical/basal cell polarityIEAbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042462Eye photoreceptor cell developmentIEAbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0043220Schmidt-Lanterman incisureIEAcellular_component
GO:0043524Negative regulation of neuron apoptotic processIDAbiological_process
GO:0045197Establishment or maintenance of epithelial cell apical/basal polarityTASbiological_process
GO:0045216Cell-cell junction organizationIMP TASbiological_process
GO:0046326Positive regulation of glucose importISSbiological_process
GO:0046903SecretionNASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048194Golgi vesicle buddingIEAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0060252Positive regulation of glial cell proliferationIMPbiological_process
GO:0061024Membrane organizationNASbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0070830Tight junction assemblyTASbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneISSbiological_process
GO:2000353Positive regulation of endothelial cell apoptotic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91366531670.01812983170.99999024730.2633632450

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4815576386
GSE13712_SHEARUp0.3787346884
GSE13712_STATICUp0.3183416074
GSE19018Down-0.4125325627
GSE19899_A1Down-0.0653193455
GSE19899_A2Down-0.4719583291
PubMed_21979375_A1Down-0.2622332012
PubMed_21979375_A2Down-0.2488669584
GSE35957Up0.1865396565
GSE36640Down-0.0989543162
GSE54402Down-0.6444303508
GSE9593Down-0.1137884291
GSE43922Down-0.2696907659
GSE24585Down-0.0749825444
GSE37065Down-0.1707766688
GSE28863_A1Down-0.6158199194
GSE28863_A2Down-0.7012793352
GSE28863_A3Up0.2440326204
GSE28863_A4Up0.2713727293
GSE48662Down-0.0353440000

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Rbt205 InhibitorDB03777 EXPT00703

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT001515pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-505-5pMIMAT0004776MIRT037939CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048786CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.