HCSGD entry for PRKCH

1. General information

Official gene symbolPRKCH
Entrez ID5583
Gene full nameprotein kinase C, eta
Other gene symbolsPKC-L PKCL PRKCL nPKC-eta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004697Protein kinase C activityTASmolecular_function
GO:0004699Calcium-independent protein kinase C activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEA ISS TAScellular_component
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0006468Protein phosphorylationIMPbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIEA ISSbiological_process
GO:0017160Ral GTPase bindingIEAmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0034351Negative regulation of glial cell apoptotic processIMPbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0045618Positive regulation of keratinocyte differentiationIEA ISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050861Positive regulation of B cell receptor signaling pathwayIMPbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0060252Positive regulation of glial cell proliferationIMPbiological_process
GO:0070528Protein kinase C signalingIEAbiological_process
GO:2000810Regulation of tight junction assemblyIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08449638310.88282707720.61116496291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0685443010
GSE13712_SHEARDown-0.3128805659
GSE13712_STATICDown-0.1534033267
GSE19018Up0.1047287713
GSE19899_A1Up0.1134787015
GSE19899_A2Up0.5978424068
PubMed_21979375_A1Up1.6917966776
PubMed_21979375_A2Up0.4375610123
GSE35957Up0.2071145411
GSE36640Up0.3955672337
GSE54402Down-0.0450907999
GSE9593Down-0.2666992646
GSE43922Up0.3406057407
GSE24585Up0.0723952957
GSE37065Up0.0494742546
GSE28863_A1Down-0.1763072388
GSE28863_A2Down-0.0600649059
GSE28863_A3Up0.0483050228
GSE28863_A4Down-0.0032412106
GSE48662Up0.2847891940

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.