HCSGD entry for KDM3A
1. General information
| Official gene symbol | KDM3A |
|---|---|
| Entrez ID | 55818 |
| Gene full name | lysine (K)-specific demethylase 3A |
| Other gene symbols | JHDM2A JHMD2A JMJD1 JMJD1A TSGA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0001047 | Core promoter binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005506 | Iron ion binding | IMP | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007290 | Spermatid nucleus elongation | IEA | biological_process |
| GO:0009755 | Hormone-mediated signaling pathway | IDA | biological_process |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0033169 | Histone H3-K9 demethylation | IDA | biological_process |
| GO:0036123 | Histone H3-K9 dimethylation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046293 | Formaldehyde biosynthetic process | IDA | biological_process |
| GO:0050681 | Androgen receptor binding | IDA | molecular_function |
| GO:0051213 | Dioxygenase activity | IEA | molecular_function |
| GO:0051573 | Negative regulation of histone H3-K9 methylation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0737447437 | 0.4956104745 | 0.5771018419 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0092046737 |
| GSE13712_SHEAR | Up | 0.0991963447 |
| GSE13712_STATIC | Down | -0.1458545399 |
| GSE19018 | Up | 0.6536660598 |
| GSE19899_A1 | Up | 0.1056985691 |
| GSE19899_A2 | Up | 0.1851792854 |
| PubMed_21979375_A1 | Up | 0.3063033490 |
| PubMed_21979375_A2 | Up | 0.6657194563 |
| GSE35957 | Down | -0.0279772597 |
| GSE36640 | Down | -0.1983071171 |
| GSE54402 | Up | 0.1634830031 |
| GSE9593 | Up | 0.1061803535 |
| GSE43922 | Up | 0.1484075937 |
| GSE24585 | Up | 0.4419699491 |
| GSE37065 | Up | 0.3910346707 |
| GSE28863_A1 | Up | 0.1554108516 |
| GSE28863_A2 | Up | 0.6858958298 |
| GSE28863_A3 | Down | -0.8604964657 |
| GSE28863_A4 | Down | -0.5161192713 |
| GSE48662 | Down | -0.3379117741 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT006439 | In situ hybridization//Luciferase reporter assay//qRT-PCR//Western blot//Immunohistochemistry//Microarray | Functional MTI | 21541331 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040574 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27114850 | HIF-1alpha stimulates the expression of KDM3A, KDM4B, KDM4C, and KDM6B, which enhance gene transcription by demethylating H3K9 and H3K27 sites (repressive epigenetic marks) |
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