HCSGD entry for SCN3B

1. General information

Official gene symbolSCN3B
Entrez ID55800
Gene full namesodium channel, voltage-gated, type III, beta subunit
Other gene symbolsHSA243396 SCNB3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIDA IEA TAScellular_component
GO:0005248Voltage-gated sodium channel activityNASmolecular_function
GO:0005886Plasma membraneIDAcellular_component
GO:0006814Sodium ion transportNASbiological_process
GO:0007399Nervous system developmentIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0010460Positive regulation of heart rateIEA ISSbiological_process
GO:0010765Positive regulation of sodium ion transportIDA IMPbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0017080Sodium channel regulator activityIDA IEA IMPmolecular_function
GO:0019233Sensory perception of painIEAbiological_process
GO:0030018Z discIEA ISScellular_component
GO:0035725Sodium ion transmembrane transportIDAbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0051899Membrane depolarizationIDAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060371Regulation of atrial cardiac muscle cell membrane depolarizationIEA IMPbiological_process
GO:0060373Regulation of ventricular cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0072659Protein localization to plasma membraneIMPbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIEA IMPbiological_process
GO:0086006Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialIDA IEA IMPmolecular_function
GO:0086010Membrane depolarization during action potentialIDA IMPbiological_process
GO:0086012Membrane depolarization during cardiac muscle cell action potentialIMPbiological_process
GO:0086014Atrial cardiac muscle cell action potentialIMPbiological_process
GO:0086070SA node cell to atrial cardiac muscle cell communicationIEA ISSbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:2000649Regulation of sodium ion transmembrane transporter activityIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13165956840.94304243000.73637327381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3339651951
GSE13712_SHEARDown-0.4683312563
GSE13712_STATICDown-0.2159669973
GSE19018Up0.0057340896
GSE19899_A1Up0.1582637627
GSE19899_A2Up0.3229889320
PubMed_21979375_A1Up0.7334891308
PubMed_21979375_A2Up0.3303289613
GSE35957Up0.0411922966
GSE36640Up0.2943706894
GSE54402Up0.1348329216
GSE9593Down-0.1877824617
GSE43922Up0.0643976214
GSE24585Up0.2016950918
GSE37065Down-0.0554826692
GSE28863_A1Down-0.0447914091
GSE28863_A2Up0.0334241394
GSE28863_A3Up0.1202980217
GSE28863_A4Up0.2497808579
GSE48662Up0.0440175676

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ZonisamideDB00909 APRD00004

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018656MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.