HCSGD entry for PRKCB
1. General information
| Official gene symbol | PRKCB |
|---|---|
| Entrez ID | 5579 |
| Gene full name | protein kinase C, beta |
| Other gene symbols | PKC-beta PKCB PRKCB1 PRKCB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA TAS | molecular_function |
| GO:0004697 | Protein kinase C activity | IEA | molecular_function |
| GO:0005080 | Protein kinase C binding | IPI | molecular_function |
| GO:0005246 | Calcium channel regulator activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0006816 | Calcium ion transport | IEA | biological_process |
| GO:0006874 | Cellular calcium ion homeostasis | IEA | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010829 | Negative regulation of glucose transport | IEA ISS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030374 | Ligand-dependent nuclear receptor transcription coactivator activity | IMP | molecular_function |
| GO:0030949 | Positive regulation of vascular endothelial growth factor receptor signaling pathway | IEA ISS | biological_process |
| GO:0035403 | Histone kinase activity (H3-T6 specific) | IDA | molecular_function |
| GO:0035408 | Histone H3-T6 phosphorylation | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0042113 | B cell activation | IEA ISS | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0042953 | Lipoprotein transport | TAS | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IEA ISS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IEA ISS | biological_process |
| GO:0046627 | Negative regulation of insulin receptor signaling pathway | ISS | biological_process |
| GO:0050681 | Androgen receptor binding | IDA | molecular_function |
| GO:0050853 | B cell receptor signaling pathway | IEA ISS | biological_process |
| GO:0050861 | Positive regulation of B cell receptor signaling pathway | IEA ISS | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IEA ISS | biological_process |
| GO:0071322 | Cellular response to carbohydrate stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6132668668 | 0.8535875651 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0097599904 |
| GSE13712_SHEAR | Down | -0.0452725180 |
| GSE13712_STATIC | Down | -0.0601232653 |
| GSE19018 | Up | 0.0198839022 |
| GSE19899_A1 | Up | 0.0974988780 |
| GSE19899_A2 | Up | 0.1169817387 |
| PubMed_21979375_A1 | Up | 0.0127509864 |
| PubMed_21979375_A2 | Down | -0.0545228195 |
| GSE35957 | Up | 0.1004665057 |
| GSE36640 | Up | 0.0427139621 |
| GSE54402 | Up | 0.2627082875 |
| GSE9593 | Up | 0.0876724748 |
| GSE43922 | Up | 0.0148968475 |
| GSE24585 | Up | 0.4556967152 |
| GSE37065 | Down | -0.1222253883 |
| GSE28863_A1 | Down | -0.2486770078 |
| GSE28863_A2 | Down | -0.2588648565 |
| GSE28863_A3 | Up | 0.2873885433 |
| GSE28863_A4 | Up | 0.0538762623 |
| GSE48662 | Up | 0.0176142313 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin E | DB00163 | NUTR00061 | EXPT03227 |
| O-Phosphoethanolamine | DB01738 | EXPT02671 | DB04403 |
| Ellagic Acid | DB08846 | DB08468 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022275 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26703243 | Overexpression of the PKC isoforms: PKCalpha, PKCbeta, and PKCzeta, but not PKCgamma, stimulated CK2 activity in the cells |
| 24295239 | In FADD-D mice, the constitutive FADD phosphorylation led to ROS accumulation (hydrogen peroxide [H(2)O(2)]), in a process that was dependent on PKCbeta and accompanied by increased PKCbeta and p66shc phosphorylation, impaired mitochondrial integrity, and enhanced sensitivity to oxidative stress-mediated apoptosis |
| 24295239 | In addition, we demonstrate that FADD phosphorylation and the recruitment of PP2A and FADD to PKCbeta are induced responses to oxidative stress, and that the extent of FADD phosphorylation in wild-type mice was augmented during aging, accompanied by impairment of the interaction between PKCbeta and PP2A |
| 24295239 | INNOVATION: The present study first addresses the role of FADD phosphorylation in aging through controlling mitochondrial ROS specifically generated by PKCbeta |
| 8733110 | We were unable to detect PKC-beta or theta in early or late passage cells |
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