HCSGD entry for PRKCA
1. General information
| Official gene symbol | PRKCA |
|---|---|
| Entrez ID | 5578 |
| Gene full name | protein kinase C, alpha |
| Other gene symbols | AAG6 PKC-alpha PKCA PRKACA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000188 | Inactivation of MAPK activity | IEA | biological_process |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0001750 | Photoreceptor outer segment | IEA | cellular_component |
| GO:0001934 | Positive regulation of protein phosphorylation | IEA | biological_process |
| GO:0001938 | Positive regulation of endothelial cell proliferation | IMP | biological_process |
| GO:0002026 | Regulation of the force of heart contraction | IEA | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0002159 | Desmosome assembly | IMP | biological_process |
| GO:0004672 | Protein kinase activity | IDA | molecular_function |
| GO:0004697 | Protein kinase C activity | ISS | molecular_function |
| GO:0004698 | Calcium-dependent protein kinase C activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006874 | Cellular calcium ion homeostasis | IEA | biological_process |
| GO:0006937 | Regulation of muscle contraction | IEA | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007190 | Activation of adenylate cyclase activity | ISS | biological_process |
| GO:0007194 | Negative regulation of adenylate cyclase activity | ISS | biological_process |
| GO:0007202 | Activation of phospholipase C activity | TAS | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010595 | Positive regulation of endothelial cell migration | IMP | biological_process |
| GO:0010613 | Positive regulation of cardiac muscle hypertrophy | ISS | biological_process |
| GO:0016056 | Rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0022400 | Regulation of rhodopsin mediated signaling pathway | TAS | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0030593 | Neutrophil chemotaxis | IEA | biological_process |
| GO:0031666 | Positive regulation of lipopolysaccharide-mediated signaling pathway | IMP | biological_process |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0034351 | Negative regulation of glial cell apoptotic process | IMP | biological_process |
| GO:0035403 | Histone kinase activity (H3-T6 specific) | IDA | molecular_function |
| GO:0035408 | Histone H3-T6 phosphorylation | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0036289 | Peptidyl-serine autophosphorylation | IEA | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043536 | Positive regulation of blood vessel endothelial cell migration | IDA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045651 | Positive regulation of macrophage differentiation | ISS | biological_process |
| GO:0045766 | Positive regulation of angiogenesis | IMP | biological_process |
| GO:0045785 | Positive regulation of cell adhesion | IMP | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
| GO:0046325 | Negative regulation of glucose import | IEA | biological_process |
| GO:0046627 | Negative regulation of insulin receptor signaling pathway | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | ISS | cellular_component |
| GO:0050729 | Positive regulation of inflammatory response | IEA | biological_process |
| GO:0050730 | Regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0050930 | Induction of positive chemotaxis | IEA | biological_process |
| GO:0070374 | Positive regulation of ERK1 and ERK2 cascade | ISS | biological_process |
| GO:0070555 | Response to interleukin-1 | IMP | biological_process |
| GO:0071322 | Cellular response to carbohydrate stimulus | IEA | biological_process |
| GO:0090330 | Regulation of platelet aggregation | IDA | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
| GO:0097193 | Intrinsic apoptotic signaling pathway | IEA | biological_process |
| GO:2000707 | Positive regulation of dense core granule biogenesis | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1773293758 | 0.0161398807 | 0.8264646257 | 0.2477452214 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2256927617 |
| GSE13712_SHEAR | Up | 1.3672498590 |
| GSE13712_STATIC | Up | 1.0557443556 |
| GSE19018 | Down | -0.0240877733 |
| GSE19899_A1 | Down | -0.2932334954 |
| GSE19899_A2 | Down | -0.7912618196 |
| PubMed_21979375_A1 | Down | -2.2506294176 |
| PubMed_21979375_A2 | Down | -0.4412650621 |
| GSE35957 | Up | 0.2056662077 |
| GSE36640 | Down | -0.9442248113 |
| GSE54402 | Down | -1.2888691767 |
| GSE9593 | Up | 0.2401832962 |
| GSE43922 | Down | -1.0391168440 |
| GSE24585 | Up | 0.5435467379 |
| GSE37065 | Down | -0.4960418382 |
| GSE28863_A1 | Up | 0.2249211741 |
| GSE28863_A2 | Up | 0.3884411307 |
| GSE28863_A3 | Up | 0.0575686423 |
| GSE28863_A4 | Up | 0.0118000485 |
| GSE48662 | Down | -0.2805697163 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Phosphatidyl serine | DB00144 | NUTR00048 |
| Vitamin E | DB00163 | NUTR00061 | EXPT03227 |
| Ingenol Mebutate | DB05013 | - |
| Ellagic Acid | DB08846 | DB08468 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT020045 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT040995 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041382 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049636 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050756 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26912086 | PKCalpha accompanied pErk1/2 to the nucleus after freeing it from PEA-15pS(104) via PKCbeta1 and then was rapidly ubiquitinated and degraded within the nucleus |
| 26912086 | Mitogen-activated protein kinase docking motif and kinase activity of PKCalpha were both required for pErk1/2 transport to the nucleus |
| 26912086 | Thus, PKCalpha downregulation is accompanied by in vivo cell proliferation, as evidenced in 7, 12-dimethylbenz(a)anthracene (DMBA)-TPA-mediated carcinogenesis |
| 26703243 | Overexpression of the PKC isoforms: PKCalpha, PKCbeta, and PKCzeta, but not PKCgamma, stimulated CK2 activity in the cells |
| 22988493 | Reduced PKC alpha Activity Induces Senescent Phenotype in Erythrocytes |
| 22988493 | Inhibition of PKC alpha by 30 muM rottlerin (R30) and 2 |
| 22988493 | We explain this antithesis by demonstrating that PMA-treated cells show reduction in the activity of PKC alpha, thereby simulating inhibition |
| 22988493 | The reduction in PKC alpha activity may be attributed to the known downregulation of PMA-activated PKC alpha, caused by its membrane translocation and proteolysis |
| 22988493 | We demonstrate membrane translocation of PKC alpha in PMA-treated cells to substantiate this inference |
| 22988493 | Thus loss of PKC alpha activity either by inhibition or downregulation can cause surface modifications which can trigger erythrophagocytosis |
| 21099353 | Senescence is driven by the activation of PKCalpha, which induces p16(Ink4a)/Rb through a MEK-dependent downregulation of Id1, and PKCdelta, which downregulates Lats1/Warts, a mitotic exit network kinase required for cytokinesis |
| 19318349 | Reactive oxygen species (ROS), which was increased in cellular senescence, significantly activated both PKCalpha and PKCbetaI |
| 19318349 | However, PKCalpha, but not PKCbetaI, regulated ROS generation and cell proliferation in senescent cells along with activation of cdk2, proven by siRNAs |
| 19318349 | Regulation of SA-pErk1/2 was also confirmed by using catalytically active PKCalpha and its DN-mutant construct |
| 18523985 | We show for the first time distinct involvement of PKC isoforms PKCdelta and PKCalpha in photoaging versus cellular senescence |
| 18523985 | While chronological aging is accompanied by overexpression and activation of PKCalpha, UV irradiation and ROS production are associated with photoaging accompanied by PKCdelta downregulation and nuclear translocation |
| 12086695 | The protein levels of PKC-alpha and PLC-gamma1 were unchanged, but those of PLD1 and PDGFR were reduced with age |
| 11480555 | Ceramide activation of protein phosphatases has been shown to promote inactivation of a number of pro-growth cellular regulators including the kinases PKC alpha and Akt, Bcl2 and the retinoblastoma protein |
| 8733110 | Late passage cells contained a slightly greater abundance of PKC alpha, gamma and epsilon than cells at an early passage |
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